Mesenchymal stem cells inhibit T-cell function through conserved induction of cellular stress

Adam G. Laing; Giorgia Fanelli; Andrei Ramirez-Valdez; Robert I. Lechler; Giovanna Lombardi; Paul T. Sharpe

doi:10.1371/journal.pone.0213170

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Peer-reviewed

Research Article

Mesenchymal stem cells inhibit T-cell function through conserved induction of cellular stress

Adam G. Laing ,

Contributed equally to this work with: Adam G. Laing, Giorgia Fanelli

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliations MRC Centre for Transplantation, School of Immunology and Microbial Sciences, King's College London, United Kingdom, Centre for Craniofacial and Regenerative Biology, King’s College London, United Kingdom
⨯
Giorgia Fanelli ,

Contributed equally to this work with: Adam G. Laing, Giorgia Fanelli

Roles Data curation, Investigation, Methodology, Validation, Writing – review & editing

Affiliation MRC Centre for Transplantation, School of Immunology and Microbial Sciences, King's College London, United Kingdom
⨯
Andrei Ramirez-Valdez,

Roles Methodology

Affiliation Centre for Craniofacial and Regenerative Biology, King’s College London, United Kingdom
⨯
Robert I. Lechler,

Roles Validation, Writing – review & editing

Affiliation MRC Centre for Transplantation, School of Immunology and Microbial Sciences, King's College London, United Kingdom
⨯
Giovanna Lombardi ,

Roles Conceptualization, Formal analysis, Supervision, Validation, Writing – original draft

* E-mail: paul.sharpe@kcl.ac.uk (GL); giovanna.lombardi@kcl.ac.uk (PTS)

Affiliation MRC Centre for Transplantation, School of Immunology and Microbial Sciences, King's College London, United Kingdom

http://orcid.org/0000-0003-4496-3215

⨯
Paul T. Sharpe

Roles Conceptualization, Formal analysis, Investigation, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: paul.sharpe@kcl.ac.uk (GL); giovanna.lombardi@kcl.ac.uk (PTS)

Affiliations MRC Centre for Transplantation, School of Immunology and Microbial Sciences, King's College London, United Kingdom, Centre for Craniofacial and Regenerative Biology, King’s College London, United Kingdom

http://orcid.org/0000-0003-2116-9561

⨯

Mesenchymal stem cells inhibit T-cell function through conserved induction of cellular stress

Adam G. Laing,
Giorgia Fanelli,
Andrei Ramirez-Valdez,
Robert I. Lechler,
Giovanna Lombardi,
Paul T. Sharpe

Published: March 14, 2019
https://doi.org/10.1371/journal.pone.0213170

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T cells
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Mesenchymal stem cells
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Tryptophan
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Cell differentiation
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Immune suppression
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Tissue repair
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