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Open Access
Peer-reviewed
Research Article
Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
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Jay H. Kalin ,
Contributed equally to this work with: Jay H. Kalin, Abdulkerim Eroglu
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
* E-mail: jkalin@bwh.harvard.edu (JHK); A.DinkovaKostova@dundee.ac.uk (ATDK)
Affiliations Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Boston, MA, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States of America, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America
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Abdulkerim Eroglu ,
Contributed equally to this work with: Jay H. Kalin, Abdulkerim Eroglu
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliations Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD, United States of America
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Hua Liu,
Roles Data curation, Formal analysis, Investigation, Supervision, Writing – review & editing
Affiliations Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD, United States of America
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W. David Holtzclaw,
Roles Data curation, Formal analysis, Investigation, Supervision, Writing – review & editing
Affiliations Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD, United States of America
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Irene Leigh,
Roles Methodology, Resources, Writing – review & editing
Affiliation Division of Cancer Research, Jacqui Wood Cancer Centre, University of Dundee, Dundee, United Kingdom
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Charlotte M. Proby,
Roles Methodology, Resources, Writing – review & editing
Affiliation Division of Cancer Research, Jacqui Wood Cancer Centre, University of Dundee, Dundee, United Kingdom
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Jed W. Fahey,
Roles Data curation, Formal analysis, Software, Supervision, Visualization, Writing – review & editing
Affiliations Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD, United States of America, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States of America
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Philip A. Cole,
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – review & editing
Affiliations Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Boston, MA, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States of America, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America
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Albena T. Dinkova-Kostova
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: jkalin@bwh.harvard.edu (JHK); A.DinkovaKostova@dundee.ac.uk (ATDK)
Affiliations Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD, United States of America, Division of Cancer Research, Jacqui Wood Cancer Centre, University of Dundee, Dundee, United Kingdom
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Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
- Jay H. Kalin,
- Abdulkerim Eroglu,
- Hua Liu,
- W. David Holtzclaw,
- Irene Leigh,
- Charlotte M. Proby,
- Jed W. Fahey,
- Philip A. Cole,
- Albena T. Dinkova-Kostova
- Published: March 13, 2019
- https://doi.org/10.1371/journal.pone.0213095