Transfusion of standard-issue packed red blood cells induces pulmonary vasoconstriction in critically ill patients after cardiac surgery—A randomized, double-blinded, clinical trial

Joanna Baron-Stefaniak; Gerda C. Leitner; Nina K. I. Küntzel; Elias L. Meyer; Michael J. Hiesmayr; Roman Ullrich; David M. Baron

doi:10.1371/journal.pone.0213000

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Open Access

Peer-reviewed

Research Article

Transfusion of standard-issue packed red blood cells induces pulmonary vasoconstriction in critically ill patients after cardiac surgery—A randomized, double-blinded, clinical trial

Joanna Baron-Stefaniak,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria

http://orcid.org/0000-0001-8081-3009

⨯
Gerda C. Leitner,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria
⨯
Nina K. I. Küntzel,

Roles Data curation, Methodology

Affiliation Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria
⨯
Elias L. Meyer,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Section for Medical Statistics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria
⨯
Michael J. Hiesmayr,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria
⨯
Roman Ullrich,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria
⨯
David M. Baron

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: david.baron@meduniwien.ac.at

Affiliation Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria
⨯

Transfusion of standard-issue packed red blood cells induces pulmonary vasoconstriction in critically ill patients after cardiac surgery—A randomized, double-blinded, clinical trial

Joanna Baron-Stefaniak,
Gerda C. Leitner,
Nina K. I. Küntzel,
Elias L. Meyer,
Michael J. Hiesmayr,
Roman Ullrich,
David M. Baron

Published: March 11, 2019
https://doi.org/10.1371/journal.pone.0213000

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Blood transfusion
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Vasoconstriction
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Blood pressure
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Pulmonary arteries
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Cardiac surgery
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Glycocalyx
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Red blood cells
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