Defects in assembly explain reduced antiviral activity of the G249D polymorphism in human TRIM5α

Sevnur Kömürlü; Margret Bradley; Nikolai Smolin; Sabrina Imam; Raymond F. Pauszek III; Seth L. Robia; David Millar; Emi E. Nakayama; Tatsuo Shioda; Edward M. Campbell

doi:10.1371/journal.pone.0212888

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Open Access

Peer-reviewed

Research Article

Defects in assembly explain reduced antiviral activity of the G249D polymorphism in human TRIM5α

Sevnur Kömürlü,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America
⨯
Margret Bradley,

Roles Data curation, Methodology

Affiliation Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America
⨯
Nikolai Smolin,

Roles Data curation, Formal analysis

Affiliation Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America
⨯
Sabrina Imam,

Roles Conceptualization, Methodology

Affiliation Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America
⨯
Raymond F. Pauszek III,

Roles Software

Affiliation Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, United States of America
⨯
Seth L. Robia,

Roles Conceptualization, Resources

Affiliation Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America
⨯
David Millar,

Roles Conceptualization

Affiliation Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, United States of America
⨯
Emi E. Nakayama,

Roles Conceptualization

Affiliation Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
⨯
Tatsuo Shioda,

Roles Conceptualization

Affiliation Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
⨯
Edward M. Campbell

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ecampbell@luc.edu

Affiliation Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America

http://orcid.org/0000-0001-5665-9195

⨯

Defects in assembly explain reduced antiviral activity of the G249D polymorphism in human TRIM5α

Sevnur Kömürlü,
Margret Bradley,
Nikolai Smolin,
Sabrina Imam,
Raymond F. Pauszek III,
Seth L. Robia,
David Millar,
Emi E. Nakayama,
Tatsuo Shioda,
Edward M. Campbell

Published: March 19, 2019
https://doi.org/10.1371/journal.pone.0212888

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