The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells

Stephen M. Matthews; Melanie A. Eshelman; Arthur S. Berg; Walter A. Koltun; Gregory S. Yochum

doi:10.1371/journal.pone.0212850

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Peer-reviewed

Research Article

The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells

Stephen M. Matthews,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Department of Biochemistry & Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America, Department of Surgery, Division of Colon and Rectal Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
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Melanie A. Eshelman,

Roles Formal analysis, Validation, Writing – review & editing

Affiliations Department of Biochemistry & Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America, Department of Surgery, Division of Colon and Rectal Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
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Arthur S. Berg,

Roles Data curation, Formal analysis

Affiliation Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
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Walter A. Koltun,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Department of Surgery, Division of Colon and Rectal Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
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Gregory S. Yochum

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Writing – review & editing

* E-mail: gsy3@psu.edu

Affiliations Department of Biochemistry & Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America, Department of Surgery, Division of Colon and Rectal Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

http://orcid.org/0000-0002-1211-3040

⨯

The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells

Stephen M. Matthews,
Melanie A. Eshelman,
Arthur S. Berg,
Walter A. Koltun,
Gregory S. Yochum

Published: February 22, 2019
https://doi.org/10.1371/journal.pone.0212850

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Gene expression
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Colon
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Guide RNA
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Luciferase
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Inflammatory bowel disease
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Single nucleotide polymorphisms
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Epithelial cells
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Transfection
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