Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes

Adelaide Tousley; Maria Iuliano; Elizabeth Weisman; Ellen Sapp; Heather Richardson; Petr Vodicka; Jonathan Alexander; Neil Aronin; Marian DiFiglia; Kimberly B. Kegel-Gleason

doi:10.1371/journal.pone.0212337

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Open Access

Peer-reviewed

Research Article

Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes

Adelaide Tousley,

Roles Conceptualization, Data curation, Writing – original draft

Affiliation Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Maria Iuliano,

Roles Data curation

Affiliation Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Elizabeth Weisman,

Roles Data curation

Affiliation Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Ellen Sapp,

Roles Data curation, Writing – review & editing

Affiliation Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Heather Richardson,

Roles Formal analysis

Affiliation Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Petr Vodicka,

Roles Formal analysis, Supervision

Affiliation Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Jonathan Alexander,

Roles Data curation

Affiliation Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Neil Aronin,

Roles Resources, Writing – review & editing

Affiliation Department of Medicine and Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Marian DiFiglia,

Roles Conceptualization, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliation Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Kimberly B. Kegel-Gleason

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: kegel@helix.mgh.harvard.edu

Affiliation Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯

Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes

Adelaide Tousley,
Maria Iuliano,
Elizabeth Weisman,
Ellen Sapp,
Heather Richardson,
Petr Vodicka,
Jonathan Alexander,
Neil Aronin,
Marian DiFiglia,
Kimberly B. Kegel-Gleason

Published: February 15, 2019
https://doi.org/10.1371/journal.pone.0212337

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Fibroblasts
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Small interfering RNA
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Cell membranes
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