Melatonin decreases M1 polarization via attenuating mitochondrial oxidative damage depending on UCP2 pathway in prorenin-treated microglia

• Li Hu ,

  Contributed equally to this work with: Li Hu, Shutian Zhang

  Roles Data curation, Project administration

  Affiliation Laboratory of Neuropharmacology and Neurotoxicology, Shanghai Key Laboratory of Bio-Energy Crops, College of Life Science, Shanghai University, Shanghai, P.R. China

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• Shutian Zhang ,

  Contributed equally to this work with: Li Hu, Shutian Zhang

  Roles Conceptualization, Data curation, Methodology, Project administration, Writing – original draft

  Affiliation Department of Physiology and Pathophysiology, Basic Medicine College, Fudan University, Shanghai, P.R. China

  ⨯
• Haoyu Wen,

  Roles Project administration

  Affiliation Department of Physiology and Pathophysiology, Basic Medicine College, Fudan University, Shanghai, P.R. China

  ⨯
• Tianfeng Liu,

  Roles Project administration

  Affiliation Laboratory of Neuropharmacology and Neurotoxicology, Shanghai Key Laboratory of Bio-Energy Crops, College of Life Science, Shanghai University, Shanghai, P.R. China

  ⨯
• Jian Cai,

  Roles Methodology

  Affiliation Department of neurology, Renji Hospital, Shanghai Jiaotong University, Shanghai, P.R. China

  ⨯
• Dongshu Du,

  Roles Resources

  Affiliation Laboratory of Neuropharmacology and Neurotoxicology, Shanghai Key Laboratory of Bio-Energy Crops, College of Life Science, Shanghai University, Shanghai, P.R. China

  ⨯
• Danian Zhu,

  Roles Resources, Supervision

  Affiliation Department of Physiology and Pathophysiology, Basic Medicine College, Fudan University, Shanghai, P.R. China

  ⨯
• Fuxue Chen ,

  Roles Funding acquisition, Resources, Supervision

  * E-mail: chenfuxue@staff.shu.edu.cn (FXC); cmxia@fudan.edu.cn (CMX)

  Affiliation Laboratory of Neuropharmacology and Neurotoxicology, Shanghai Key Laboratory of Bio-Energy Crops, College of Life Science, Shanghai University, Shanghai, P.R. China

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• Chunmei Xia

  Roles Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: chenfuxue@staff.shu.edu.cn (FXC); cmxia@fudan.edu.cn (CMX)

  Affiliation Department of Physiology and Pathophysiology, Basic Medicine College, Fudan University, Shanghai, P.R. China

  http://orcid.org/0000-0001-9845-9685

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