Using topic modeling via non-negative matrix factorization to identify relationships between genetic variants and disease phenotypes: A case study of Lipoprotein(a) (LPA)

• Juan Zhao,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States of America

  http://orcid.org/0000-0003-1429-0662

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• QiPing Feng,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, United States of America

  http://orcid.org/0000-0002-6213-793X

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• Patrick Wu,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States of America, Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN, United States of America

  http://orcid.org/0000-0002-1437-6688

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• Jeremy L. Warner,

  Roles Formal analysis, Validation, Writing – review & editing

  Affiliations Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States of America, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America

  http://orcid.org/0000-0002-2851-7242

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• Joshua C. Denny,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

  Affiliations Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States of America, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• Wei-Qi Wei

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: wei-qi.wei@vumc.org

  Affiliation Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States of America

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