The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

• You Xu,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: School of Life Science, Westlake University, Hangzhou, China

  Affiliation Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden

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• Olof Gissberg,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden

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• Y. Vladimir Pabon-Martinez,

  Roles Investigation, Methodology, Writing – review & editing

  Current address: Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia

  Affiliation Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden

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• Jesper Wengel,

  Roles Resources, Writing – review & editing

  Affiliation Biomolecular Nanoscale Engineering Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense M, Denmark

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• Karin E. Lundin,

  Roles Conceptualization, Data curation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden

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• C. I. Edvard Smith,

  Roles Conceptualization, Data curation, Funding acquisition, Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden

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• Rula Zain,

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Writing – review & editing

  Affiliations Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden, Department of Clinical Genetics, Centre for Rare Diseases, Karolinska University Hospital, Stockholm, Sweden

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• Lennart Nilsson,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Software, Supervision, Writing – review & editing

  Affiliation Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden

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• Alessandra Villa

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: alessandra.villa@ki.se

  Affiliation Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden

  http://orcid.org/0000-0002-9573-0326

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