Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage

Sunao Shimada; Tetsuya Tanigawa; Toshio Watanabe; Akinobu Nakata; Naoki Sugimura; Shigehiro Itani; Akira Higashimori; Yuji Nadatani; Koji Otani; Koichi Taira; Shuhei Hosomi; Yasuaki Nagami; Fumio Tanaka; Noriko Kamata; Hirokazu Yamagami; Masatsugu Shiba; Yasuhiro Fujiwara

doi:10.1371/journal.pone.0211436

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Open Access

Peer-reviewed

Research Article

Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage

Sunao Shimada ,

Contributed equally to this work with: Sunao Shimada, Tetsuya Tanigawa

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Supervision, Visualization, Writing – original draft

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Tetsuya Tanigawa ,

Contributed equally to this work with: Sunao Shimada, Tetsuya Tanigawa

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: ttanigawa@med.osaka-cu.ac.jp

Affiliations Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan, SAMURAI GI Research Centre, Osaka City University Graduate School of Medicine, Osaka, Japan

http://orcid.org/0000-0002-9305-1637

⨯
Toshio Watanabe,

Roles Supervision, Validation, Visualization

Affiliations Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan, SAMURAI GI Research Centre, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Akinobu Nakata,

Roles Investigation, Validation

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Naoki Sugimura,

Roles Investigation, Validation

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Shigehiro Itani,

Roles Investigation, Validation

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Akira Higashimori,

Roles Investigation, Validation

Affiliations Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan, SAMURAI GI Research Centre, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Yuji Nadatani,

Roles Data curation, Investigation, Methodology, Validation, Visualization

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Koji Otani,

Roles Investigation, Methodology, Validation, Visualization

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Koichi Taira,

Roles Investigation, Validation

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Shuhei Hosomi,

Roles Validation

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Yasuaki Nagami,

Roles Validation

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Fumio Tanaka,

Roles Validation

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Noriko Kamata,

Roles Validation

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Hirokazu Yamagami,

Roles Validation

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
Masatsugu Shiba,

Roles Validation

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
[ ... ],
Yasuhiro Fujiwara

Roles Validation

Affiliations Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan, SAMURAI GI Research Centre, Osaka City University Graduate School of Medicine, Osaka, Japan
⨯
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Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage

Sunao Shimada,
Tetsuya Tanigawa,
Toshio Watanabe,
Akinobu Nakata,
Naoki Sugimura,
Shigehiro Itani,
Akira Higashimori,
Yuji Nadatani,
Koji Otani,
Koichi Taira

Published: February 20, 2019
https://doi.org/10.1371/journal.pone.0211436

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