Physical stimulation by REAC and BMP4/WNT-1 inhibitor synergistically enhance cardiogenic commitment in iPSCs

• Valentina Basoli,

  Roles Conceptualization, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biomedical Sciences, University of Sassari, Sassari, Italy, Research Department, Rinaldi Fontani Foundation, Florence, Italy, Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria

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• Sara Santaniello ,

  Contributed equally to this work with: Sara Santaniello, Salvatore Rinaldi

  Roles Investigation, Visualization, Writing – review & editing

  Affiliations Department of Biomedical Sciences, University of Sassari, Sassari, Italy, National Laboratory of Molecular Biology and Stem Cell Engineering - National Institute of Biostructures and Biosystems-Eldor Lab, at Innovation Accelerators, CNR, Bologna, Italy

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• Salvatore Rinaldi ,

  Contributed equally to this work with: Sara Santaniello, Salvatore Rinaldi

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  * E-mail: srinaldi@irf.it

  Affiliations Research Department, Rinaldi Fontani Foundation, Florence, Italy, Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence, Italy, IRF Shanghai Medical Sciences, Shanghai, China

  http://orcid.org/0000-0002-8961-6316

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• Vania Fontani,

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  Affiliations Research Department, Rinaldi Fontani Foundation, Florence, Italy, Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence, Italy, IRF Shanghai Medical Sciences, Shanghai, China

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• Gianfranco Pigliaru,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliations Department of Biomedical Sciences, University of Sassari, Sassari, Italy, National Laboratory of Molecular Biology and Stem Cell Engineering - National Institute of Biostructures and Biosystems-Eldor Lab, at Innovation Accelerators, CNR, Bologna, Italy

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• Matthias Wieser,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliations Evercyte GmbH, Vienna, Austria, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria

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• Agata Strajeriu,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliations Evercyte GmbH, Vienna, Austria, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria

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• Alessandro Castagna,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliation Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence, Italy

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• Heinz Redl,

  Roles Supervision, Writing – review & editing

  Affiliations Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria

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• Carlo Ventura,

  Roles Supervision, Writing – review & editing

  Affiliations National Laboratory of Molecular Biology and Stem Cell Engineering - National Institute of Biostructures and Biosystems-Eldor Lab, at Innovation Accelerators, CNR, Bologna, Italy, Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence, Italy

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• Regina Grillari,

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria, Evercyte GmbH, Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria

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• Margherita Maioli

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biomedical Sciences, University of Sassari, Sassari, Italy, IRF Shanghai Medical Sciences, Shanghai, China, Center for developmental biology and reprogramming - CEDEBIOR, Department of Biomedical Sciences, University of Sassari and National Institute of Biostructures and Biosystems, Sassari, Italy

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