Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma

Andrew J. Gunderson; Tomoko Yamazaki; Kayla McCarty; Michaela Phillips; Alejandro Alice; Shelly Bambina; Lauren Zebertavage; David Friedman; Benjamin Cottam; Pippa Newell; Michael J. Gough; Marka R. Crittenden; Pieter Van der Veken; Kristina H. Young

doi:10.1371/journal.pone.0211117

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Open Access

Peer-reviewed

Research Article

Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma

Andrew J. Gunderson,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America
⨯
Tomoko Yamazaki,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America
⨯
Kayla McCarty,

Roles Conceptualization, Data curation, Investigation, Methodology, Software, Validation, Visualization

Affiliation Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America
⨯
Michaela Phillips,

Roles Data curation, Methodology, Software, Validation, Visualization

Affiliation Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America
⨯
Alejandro Alice,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America
⨯
Shelly Bambina,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization

Affiliation Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America
⨯
Lauren Zebertavage,

Roles Data curation, Formal analysis, Methodology, Visualization

Affiliation Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America
⨯
David Friedman,

Roles Data curation, Investigation, Software, Supervision, Validation, Visualization

Affiliation Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America
⨯
Benjamin Cottam,

Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization

Affiliation Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America
⨯
Pippa Newell,

Roles Conceptualization, Methodology

Affiliations Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America, Gastrointestinal & Minimally Invasive Surgery, The Oregon Clinic, Portland, OR, United States of America
⨯
Michael J. Gough,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America

http://orcid.org/0000-0002-5575-0074

⨯
Marka R. Crittenden,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America, Radiation Oncology, The Oregon Clinic, Portland, OR, United States of America
⨯
Pieter Van der Veken,

Roles Conceptualization, Methodology, Resources

Affiliation Medicinal Chemistry (UAMC), Department of Pharmaceutical Sciences, University of Antwerp (UA), Antwerp, Belgium
⨯
Kristina H. Young

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: kristina.young@providence.org

Affiliations Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America, Radiation Oncology, The Oregon Clinic, Portland, OR, United States of America

http://orcid.org/0000-0002-3363-0063

⨯

Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma

Andrew J. Gunderson,
Tomoko Yamazaki,
Kayla McCarty,
Michaela Phillips,
Alejandro Alice,
Shelly Bambina,
Lauren Zebertavage,
David Friedman,
Benjamin Cottam,
Pippa Newell

Published: February 6, 2019
https://doi.org/10.1371/journal.pone.0211117

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