Castration-resistant prostate cancer: Androgen receptor inactivation induces telomere DNA damage, and damage response inhibition leads to cell death

Vidyavathi Reddy; Asm Iskander; Clara Hwang; George Divine; Mani Menon; Evelyn R. Barrack; G. Prem-Veer Reddy; Sahn-Ho Kim

doi:10.1371/journal.pone.0211090

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Open Access

Peer-reviewed

Research Article

Castration-resistant prostate cancer: Androgen receptor inactivation induces telomere DNA damage, and damage response inhibition leads to cell death

Vidyavathi Reddy,

Roles Formal analysis

Affiliation Department of Urology, Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, United States of America
⨯
Asm Iskander,

Roles Formal analysis

Affiliation Department of Urology, Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, United States of America
⨯
Clara Hwang,

Roles Supervision, Writing – review & editing

Affiliation Department of Oncology and Hematology, Henry Ford Hospital, Detroit, MI, United States of America
⨯
George Divine,

Roles Data curation

Affiliation Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, United States of America
⨯
Mani Menon,

Roles Supervision, Writing – review & editing

Affiliation Department of Urology, Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, United States of America
⨯
Evelyn R. Barrack,

Roles Supervision, Writing – review & editing

Affiliation Department of Urology, Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, United States of America
⨯
G. Prem-Veer Reddy,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Department of Urology, Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, United States of America
⨯
Sahn-Ho Kim

Roles Conceptualization, Data curation, Formal analysis, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: skim3@hfhs.org

Affiliation Department of Urology, Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, United States of America

http://orcid.org/0000-0002-2574-9902

⨯

Castration-resistant prostate cancer: Androgen receptor inactivation induces telomere DNA damage, and damage response inhibition leads to cell death

Vidyavathi Reddy,
Asm Iskander,
Clara Hwang,
George Divine,
Mani Menon,
Evelyn R. Barrack,
G. Prem-Veer Reddy,
Sahn-Ho Kim

Published: May 13, 2019
https://doi.org/10.1371/journal.pone.0211090

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Telomeres
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DNA damage
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Cancer treatment
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Cancers and neoplasms
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Prostate cancer
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Cell death
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DNA repair
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Small interfering RNA
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