Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator

• Abdallah M. Abdallah ,

  Contributed equally to this work with: Abdallah M. Abdallah, Eveline M. Weerdenburg

  Roles Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: abdallah.abdallah@kaust.edu.sa (AMA); w.bitter@vumc.nl (WB); arnab.pain@kaust.edu.sa (AP)

  Affiliation Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia

  http://orcid.org/0000-0002-3984-576X

  ⨯
• Eveline M. Weerdenburg ,

  Contributed equally to this work with: Abdallah M. Abdallah, Eveline M. Weerdenburg

  Roles Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands

  ⨯
• Qingtian Guan,

  Roles Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia

  ⨯
• Roy Ummels,

  Roles Methodology

  Affiliation Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands

  ⨯
• Stephanie Borggreve,

  Roles Methodology

  Affiliation Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands

  ⨯
• Sabir A. Adroub,

  Roles Methodology

  Affiliation Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia

  ⨯
• Tareq B. Malas,

  Roles Methodology

  Affiliation Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia

  ⨯
• Raeece Naeem,

  Roles Methodology

  Affiliation Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia

  ⨯
• Huoming Zhang,

  Roles Methodology

  Affiliation Bioscience Core Laboratory, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia

  ⨯
• Thomas D. Otto,

  Roles Methodology

  Affiliation Pathogen Genomics, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

  ⨯
• Wilbert Bitter ,

  Roles Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: abdallah.abdallah@kaust.edu.sa (AMA); w.bitter@vumc.nl (WB); arnab.pain@kaust.edu.sa (AP)

  ¶‡ These authors also contributed equally to this work.

  Affiliation Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands

  http://orcid.org/0000-0001-8347-6511

  ⨯
• Arnab Pain

  Roles Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – review & editing

  * E-mail: abdallah.abdallah@kaust.edu.sa (AMA); w.bitter@vumc.nl (WB); arnab.pain@kaust.edu.sa (AP)

  ¶‡ These authors also contributed equally to this work.

  Affiliation Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Kingdom of Saudi Arabia

  http://orcid.org/0000-0002-1755-2819

  ⨯