Graft-implanted, enzyme responsive, tacrolimus-eluting hydrogel enables long-term survival of orthotopic porcine limb vascularized composite allografts: A proof of concept study

• C. Anton Fries ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: antonfries@gmail.com

  Affiliations United States Army Institute of Surgical Research, San Antonio, TX, United States of America, Royal Centre for Defence Medicine, ICT Centre, Birmingham, United Kingdom

  http://orcid.org/0000-0003-0128-5688

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• Shari D. Lawson,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation United States Army Institute of Surgical Research, San Antonio, TX, United States of America

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• Lin C. Wang,

  Roles Data curation, Formal analysis, Investigation, Project administration, Writing – review & editing

  Affiliation United States Army Institute of Surgical Research, San Antonio, TX, United States of America

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• Kai V. Slaughter,

  Roles Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, United States of America

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• Praveen K. Vemula,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Institute for Stem Cell Biology and Regenerative Medicine (inStem), UAS-GKVK Campus, Bangalore, India

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• Ashish Dhayani,

  Roles Formal analysis, Resources, Validation, Writing – review & editing

  Affiliations Institute for Stem Cell Biology and Regenerative Medicine (inStem), UAS-GKVK Campus, Bangalore, India, The School of Chemical and Biotechnology, SASTRA University, Thanjavur, India

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• Nitin Joshi,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliations Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, United States of America, Harvard Medical School, Boston, MA, United States of America

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• Jeffrey M. Karp,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – review & editing

  Affiliations Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, United States of America, Harvard Medical School, Boston, MA, United States of America

  http://orcid.org/0000-0002-4752-7374

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• Rory F. Rickard,

  Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Royal Centre for Defence Medicine, ICT Centre, Birmingham, United Kingdom

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• Vijay S. Gorantla,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliations Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, United States of America, RESTOR Program, 59th MDW/ Science and Technology, Joint Base San Antonio, TX, United States of America

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• Michael R. Davis

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations United States Army Institute of Surgical Research, San Antonio, TX, United States of America, RESTOR Program, 59th MDW/ Science and Technology, Joint Base San Antonio, TX, United States of America

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