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Open Access

Peer-reviewed

Research Article

Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design

Atefeh Ghorbani Aghdam,

Roles Data curation, Formal analysis, Writing – original draft

Affiliation Biopharmaceutical Research Center, Aryogen Pharmed Inc., Alborz University of Medical Science, Karaj, Iran
⨯
Saeed Moradhaseli,

Roles Methodology, Validation, Visualization

Affiliation Biopharmaceutical Research Center, Aryogen Pharmed Inc., Alborz University of Medical Science, Karaj, Iran
⨯
Farnoush Jafari,

Roles Conceptualization, Data curation, Investigation

Affiliation Biopharmaceutical Research Center, Aryogen Pharmed Inc., Alborz University of Medical Science, Karaj, Iran
⨯
Paria Motahari,

Roles Formal analysis, Investigation, Software, Writing – review & editing

Affiliation Biopharmaceutical Research Center, Aryogen Pharmed Inc., Alborz University of Medical Science, Karaj, Iran
⨯
Sepideh Samavat,

Roles Data curation, Formal analysis, Resources, Supervision

Affiliation Biopharmaceutical Research Center, Aryogen Pharmed Inc., Alborz University of Medical Science, Karaj, Iran
⨯
Rasoul Mahboudi,

Roles Data curation, Formal analysis, Resources, Supervision

Affiliation Biopharmaceutical Research Center, Aryogen Pharmed Inc., Alborz University of Medical Science, Karaj, Iran
⨯
Shayan Maleknia

Roles Funding acquisition, Project administration, Supervision

* E-mail: Maleknias@aryogen.com

Affiliation Biopharmaceutical Research Center, Aryogen Pharmed Inc., Alborz University of Medical Science, Karaj, Iran
⨯

Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design

Atefeh Ghorbani Aghdam,
Saeed Moradhaseli,
Farnoush Jafari,
Paria Motahari,
Sepideh Samavat,
Rasoul Mahboudi,
Shayan Maleknia

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Published: January 16, 2019
https://doi.org/10.1371/journal.pone.0210712

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Protein folding
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Protein misfolding
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Protein expression
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CHO cells
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Cell cultures
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Analysis of variance
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Recombinant proteins
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Cell fusion
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