Presence, persistence and effects of pre-treatment HIV-1 drug resistance variants detected using next generation sequencing: A Retrospective longitudinal study from rural coastal Kenya

Amin S. Hassan; David F. Bibby; Shalton M. Mwaringa; Clara A. Agutu; Kennedy K. Ndirangu; Eduard J. Sanders; Patricia A. Cane; Jean L. Mbisa; James A. Berkley

doi:10.1371/journal.pone.0210559

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Open Access

Peer-reviewed

Research Article

Presence, persistence and effects of pre-treatment HIV-1 drug resistance variants detected using next generation sequencing: A Retrospective longitudinal study from rural coastal Kenya

Amin S. Hassan ,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

* E-mail: ahassan@kemri-wellcome.org

Affiliation KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya

http://orcid.org/0000-0001-5296-4264

⨯
David F. Bibby,

Roles Data curation, Writing – review & editing

Affiliation Virus Reference Department, Public Health England, London, United Kingdom
⨯
Shalton M. Mwaringa,

Roles Investigation, Writing – review & editing

Affiliation KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya
⨯
Clara A. Agutu,

Roles Investigation, Writing – review & editing

Affiliation KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya
⨯
Kennedy K. Ndirangu,

Roles Investigation, Writing – review & editing

Affiliation Kilifi County Hospital, Kilifi, Kenya
⨯
Eduard J. Sanders,

Roles Supervision, Writing – review & editing

Affiliations KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya, Centre for Tropical Medicine & Global Health, University of Oxford, Oxford, United Kingdom
⨯
Patricia A. Cane,

Roles Supervision, Writing – review & editing

Affiliation Virus Reference Department, Public Health England, London, United Kingdom
⨯
Jean L. Mbisa,

Roles Conceptualization, Formal analysis, Supervision, Writing – review & editing

Affiliation Virus Reference Department, Public Health England, London, United Kingdom
⨯
James A. Berkley

Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya, Centre for Tropical Medicine & Global Health, University of Oxford, Oxford, United Kingdom

http://orcid.org/0000-0002-1236-849X

⨯

Presence, persistence and effects of pre-treatment HIV-1 drug resistance variants detected using next generation sequencing: A Retrospective longitudinal study from rural coastal Kenya

Amin S. Hassan,
David F. Bibby,
Shalton M. Mwaringa,
Clara A. Agutu,
Kennedy K. Ndirangu,
Eduard J. Sanders,
Patricia A. Cane,
Jean L. Mbisa,
James A. Berkley

Published: February 13, 2019
https://doi.org/10.1371/journal.pone.0210559

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