A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

Joshua A. Sommers; Tomasz Kulikowicz; Deborah L. Croteau; Thomas Dexheimer; Dorjbal Dorjsuren; Ajit Jadhav; David J. Maloney; Anton Simeonov; Vilhelm A. Bohr; Robert M. Brosh Jr.

doi:10.1371/journal.pone.0210525

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Open Access

Peer-reviewed

Research Article

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

Joshua A. Sommers,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

http://orcid.org/0000-0003-0859-6286

⨯
Tomasz Kulikowicz,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Deborah L. Croteau,

Roles Data curation, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliation Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Thomas Dexheimer,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Dorjbal Dorjsuren,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Ajit Jadhav,

Roles Conceptualization, Data curation, Formal analysis, Project administration, Software, Supervision

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
David J. Maloney,

Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Anton Simeonov,

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Vilhelm A. Bohr,

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Robert M. Brosh Jr.

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: broshr@mail.nih.gov

Affiliation Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

http://orcid.org/0000-0003-2676-4327

⨯

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

Joshua A. Sommers,
Tomasz Kulikowicz,
Deborah L. Croteau,
Thomas Dexheimer,
Dorjbal Dorjsuren,
Ajit Jadhav,
David J. Maloney,
Anton Simeonov,
Vilhelm A. Bohr,
Robert M. Brosh Jr.

Published: January 9, 2019
https://doi.org/10.1371/journal.pone.0210525

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