Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease

Fatma N. Hamed; Annika Åstrand; Marta Bertolini; Alfredo Rossi; Afsaneh Maleki-Dizaji; Andrew G. Messenger; Andrew J. G. McDonagh; Rachid Tazi-Ahnini

doi:10.1371/journal.pone.0210308

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Open Access

Peer-reviewed

Research Article

Alopecia areata patients show deficiency of FOXP₃+CD₃₉+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease

Fatma N. Hamed,

Roles Data curation, Investigation, Writing – original draft

Affiliation Department of Infection, Immunity and Cardiovascular disease, The Medical School, University of Sheffield, Sheffield, United Kingdom
⨯
Annika Åstrand,

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

Affiliation Respiratory, Inflammation and Autoimmunity IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

http://orcid.org/0000-0002-4231-6682

⨯
Marta Bertolini,

Roles Data curation, Formal analysis, Supervision, Writing – review & editing

Affiliation Laboratory for Hair Research and Regenerative Medicine, Department of Dermatology, University of Münster, Germany
⨯
Alfredo Rossi,

Roles Investigation

Affiliation Dermatology Centre, University of Manchester, Salford Royal NHS Foundation Trust, Salford, United Kingdom
⨯
Afsaneh Maleki-Dizaji,

Roles Formal analysis

Affiliation Dermatology department, Sheffield Teaching Hospitals, Sheffield, United Kingdom
⨯
Andrew G. Messenger,

Roles Supervision, Writing – review & editing

Affiliation Department of Dermatology, Royal Hallamshire Hospital, Sheffield, United Kingdom
⨯
Andrew J. G. McDonagh ,

Contributed equally to this work with: Andrew J. G. McDonagh, Rachid Tazi-Ahnini

Roles Supervision, Writing – review & editing

Affiliation Dermatology department, Sheffield Teaching Hospitals, Sheffield, United Kingdom
⨯
Rachid Tazi-Ahnini

Contributed equally to this work with: Andrew J. G. McDonagh, Rachid Tazi-Ahnini

Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – review & editing

* E-mail: r.taziahnini@shef.ac.uk

Affiliation Department of Infection, Immunity and Cardiovascular disease, The Medical School, University of Sheffield, Sheffield, United Kingdom
⨯

Alopecia areata patients show deficiency of FOXP₃+CD₃₉+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease

Fatma N. Hamed,
Annika Åstrand,
Marta Bertolini,
Alfredo Rossi,
Afsaneh Maleki-Dizaji,
Andrew G. Messenger,
Andrew J. G. McDonagh,
Rachid Tazi-Ahnini

Published: July 5, 2019
https://doi.org/10.1371/journal.pone.0210308

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