Biased efficacy estimates in phase-III dengue vaccine trials due to heterogeneous exposure and differential detectability of primary infections across trial arms

• Guido España ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

  * E-mail: guido.espana@nd.edu (GE); taperkins@nd.edu (TAP)

  Affiliation Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States of America

  http://orcid.org/0000-0002-9915-8056

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• Cosmina Hogea,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation GlaxoSmithKline, Rockville, MD, United States of America

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• Adrienne Guignard,

  Roles Conceptualization, Writing – review & editing

  Affiliation GlaxoSmithKline, Rockville, MD, United States of America

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• Quirine A. ten Bosch,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States of America

  http://orcid.org/0000-0002-5227-1406

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• Amy C. Morrison,

  Roles Writing – review & editing

  Affiliations United States Naval Medical Research Unit No. 6, Lima, Peru, Department of Entomology and Nematology, University of California, Davis, CA, United States of America

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• David L. Smith,

  Roles Writing – review & editing

  Affiliation Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States of America

  http://orcid.org/0000-0003-4367-3849

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• Thomas W. Scott,

  Roles Writing – review & editing

  Affiliation Department of Entomology and Nematology, University of California, Davis, CA, United States of America

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• Alexander Schmidt,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation GlaxoSmithKline, Rockville, MD, United States of America

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• T. Alex Perkins

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Visualization, Writing – original draft

  * E-mail: guido.espana@nd.edu (GE); taperkins@nd.edu (TAP)

  Affiliation Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States of America

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