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Open Access
Peer-reviewed
Research Article
Deletion of genes involved in the ketogluconate metabolism, Entner-Doudoroff pathway, and glucose dehydrogenase increase local and invasive virulence phenotypes in Streptococcus pneumoniae
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Fen Z. Hu ,
Contributed equally to this work with: Fen Z. Hu, Jarosław E. Król
Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Writing – original draft
* E-mail: fhu168168@gmail.com (FZH); GE33@drexel.edu (GDE)
Affiliations Center for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States of America, Department of Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, PA, United States of America
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Jarosław E. Król ,
Contributed equally to this work with: Fen Z. Hu, Jarosław E. Król
Roles Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliations Center for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States of America, Center for Advanced Microbial Processing, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, United States of America
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Chen Hsuan Sherry Tsai,
Roles Conceptualization, Investigation
Affiliations Center for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States of America
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Rory A. Eutsey,
Roles Methodology
Affiliation Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States of America
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Luisa N. Hiller,
Roles Conceptualization
Affiliation Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States of America
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Bhaswati Sen,
Roles Investigation, Methodology
Affiliations Center for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States of America, Center for Advanced Microbial Processing, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, United States of America
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Azad Ahmed,
Roles Investigation
Affiliations Center for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States of America, Center for Advanced Microbial Processing, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, United States of America
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Todd Hillman,
Roles Conceptualization, Resources
Affiliation Center of Excellence in Biofilm Research, Allegheny Health Network, Pittsburgh, PA, United States of America
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Farrel J. Buchinsky,
Roles Resources
Affiliation Center of Excellence in Biofilm Research, Allegheny Health Network, Pittsburgh, PA, United States of America
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Laura Nistico,
Roles Investigation
Affiliation Center of Excellence in Biofilm Research, Allegheny Health Network, Pittsburgh, PA, United States of America
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Bethany Dice,
Roles Investigation
Affiliation Center of Excellence in Biofilm Research, Allegheny Health Network, Pittsburgh, PA, United States of America
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Mark Longwell,
Roles Resources
Affiliation Center of Excellence in Biofilm Research, Allegheny Health Network, Pittsburgh, PA, United States of America
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Edward Horsey,
Roles Resources
Affiliation Center of Excellence in Biofilm Research, Allegheny Health Network, Pittsburgh, PA, United States of America
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Garth D. Ehrlich
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: fhu168168@gmail.com (FZH); GE33@drexel.edu (GDE)
Affiliations Center for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, United States of America, Department of Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, PA, United States of America, Center for Advanced Microbial Processing, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, United States of America, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States of America, Center of Excellence in Biofilm Research, Allegheny Health Network, Pittsburgh, PA, United States of America
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Deletion of genes involved in the ketogluconate metabolism, Entner-Doudoroff pathway, and glucose dehydrogenase increase local and invasive virulence phenotypes in Streptococcus pneumoniae
- Fen Z. Hu,
- Jarosław E. Król,
- Chen Hsuan Sherry Tsai,
- Rory A. Eutsey,
- Luisa N. Hiller,
- Bhaswati Sen,
- Azad Ahmed,
- Todd Hillman,
- Farrel J. Buchinsky,
- Laura Nistico
- Published: January 8, 2019
- https://doi.org/10.1371/journal.pone.0209688