A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn’s disease patients

• Andrew Y. F. Li Yim ,

  Contributed equally to this work with: Andrew Y. F. Li Yim, Jessica R. de Bruyn, Nicolette W. Duijvis

  Roles Data curation, Formal analysis, Software, Visualization, Writing – original draft

  Affiliations Genome Diagnostics Laboratory, Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands, Epigenetics Discovery Performance Unit, GlaxoSmithKline, Stevenage, United Kingdom

  http://orcid.org/0000-0002-0754-0953

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• Jessica R. de Bruyn ,

  Contributed equally to this work with: Andrew Y. F. Li Yim, Jessica R. de Bruyn, Nicolette W. Duijvis

  Roles Investigation, Writing – original draft

  Affiliations Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands, Department of Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

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• Nicolette W. Duijvis ,

  Contributed equally to this work with: Andrew Y. F. Li Yim, Jessica R. de Bruyn, Nicolette W. Duijvis

  Roles Investigation, Writing – original draft

  Affiliation Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

  http://orcid.org/0000-0002-3929-7978

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• Catriona Sharp,

  Roles Supervision, Writing – review & editing

  Affiliation Epigenetics Discovery Performance Unit, GlaxoSmithKline, Stevenage, United Kingdom

  ⨯
• Enrico Ferrero,

  Roles Supervision, Writing – review & editing

  Current address: Autoimmunity Transplantation and Inflammation Bioinformatics, Novartis Institutes for Biomedical Research, Basel, Switzerland.

  Affiliation Computational Biology, Target Sciences, GlaxoSmithKline, Stevenage, United Kingdom

  http://orcid.org/0000-0002-8362-100X

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• Wouter J. de Jonge,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

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• Manon E. Wildenberg,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  Affiliation Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

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• Marcel M. A. M. Mannens,

  Roles Supervision, Writing – review & editing

  Affiliation Genome Diagnostics Laboratory, Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

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• Christianne J. Buskens,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

  ⨯
• Geert R. D’Haens,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Department of Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

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• Peter Henneman ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Genome Diagnostics Laboratory, Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

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• Anje A. te Velde

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: a.a.tevelde@amc.nl

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

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