Mitochondrial genome and functional defects in osteosarcoma are associated with their aggressive phenotype

Martina Jackson; Nicole Serada; Maura Sheehan; Satish Srinivasan; Nicola Mason; Manti Guha; Narayan Avadhani

doi:10.1371/journal.pone.0209489

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Peer-reviewed

Research Article

Mitochondrial genome and functional defects in osteosarcoma are associated with their aggressive phenotype

Martina Jackson ,

Contributed equally to this work with: Martina Jackson, Nicole Serada

Roles Investigation

Affiliation Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Nicole Serada ,

Contributed equally to this work with: Martina Jackson, Nicole Serada

Roles Investigation

Affiliation Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Maura Sheehan,

Roles Investigation

Affiliation Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Satish Srinivasan,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Nicola Mason,

Roles Resources, Writing – review & editing

Affiliation Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Manti Guha ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: manti@upenn.edu (MG); narayan@upenn.edu (NA)

Affiliation Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0003-1576-3580

⨯
Narayan Avadhani

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: manti@upenn.edu (MG); narayan@upenn.edu (NA)

Affiliation Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Mitochondrial genome and functional defects in osteosarcoma are associated with their aggressive phenotype

Martina Jackson,
Nicole Serada,
Maura Sheehan,
Satish Srinivasan,
Nicola Mason,
Manti Guha,
Narayan Avadhani

Published: December 21, 2018
https://doi.org/10.1371/journal.pone.0209489

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Mitochondrial DNA
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Osteosarcoma
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