Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment

Nan Ni; Yang Gao; Xin Fang; Maria Melgar; David F. Vincent; John P. Lydon; Laurent Bartholin; Qinglei Li

doi:10.1371/journal.pone.0209417

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Peer-reviewed

Research Article

Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment

Nan Ni ,

Contributed equally to this work with: Nan Ni, Yang Gao, Xin Fang

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America
⨯
Yang Gao ,

Contributed equally to this work with: Nan Ni, Yang Gao, Xin Fang

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America
⨯
Xin Fang ,

Contributed equally to this work with: Nan Ni, Yang Gao, Xin Fang

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America
⨯
Maria Melgar,

Roles Investigation

Affiliation Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America
⨯
David F. Vincent,

Roles Resources

Affiliation Cancer Research United Kingdom Beatson Institute, Garscube Estate, Glasgow, United Kingdom
⨯
John P. Lydon,

Roles Resources

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Laurent Bartholin,

Roles Resources

Affiliation Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre Léon Bérard, Lyon, France
⨯
Qinglei Li

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Writing – original draft

* E-mail: qli@cvm.tamu.edu

Affiliation Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America

http://orcid.org/0000-0002-4515-7963

⨯

Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment

Nan Ni,
Yang Gao,
Xin Fang,
Maria Melgar,
David F. Vincent,
John P. Lydon,
Laurent Bartholin,
Qinglei Li

Published: December 14, 2018
https://doi.org/10.1371/journal.pone.0209417

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Uterus
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Mouse models
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TGF-beta signaling cascade
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Epithelial cells
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Stromal cells
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Cell differentiation
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Immunofluorescence
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Gland development
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