Induction of AMPK activation by N,N’-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers

Jeremy Johnson; Piotr Rychahou; Vitaliy M. Sviripa; Heidi L. Weiss; Chunming Liu; David S. Watt; B. Mark Evers

doi:10.1371/journal.pone.0209392

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Peer-reviewed

Research Article

Induction of AMPK activation by N,N’-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers

Jeremy Johnson,

Roles Conceptualization, Investigation, Writing – original draft

Affiliation Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Piotr Rychahou,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America, Department of Surgery, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Vitaliy M. Sviripa,

Roles Resources

Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Heidi L. Weiss,

Roles Formal analysis

Affiliation Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Chunming Liu,

Roles Resources

Affiliations Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America, Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
David S. Watt,

Roles Resources, Writing – review & editing

Affiliations Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America, Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky, United States of America
⨯
B. Mark Evers

Roles Funding acquisition, Writing – review & editing

* E-mail: mark.evers@uky.edu

Affiliations Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America, Department of Surgery, University of Kentucky, Lexington, Kentucky, United States of America

http://orcid.org/0000-0002-9425-2342

⨯

Induction of AMPK activation by N,N’-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers

Jeremy Johnson,
Piotr Rychahou,
Vitaliy M. Sviripa,
Heidi L. Weiss,
Chunming Liu,
David S. Watt,
B. Mark Evers

Published: March 15, 2019
https://doi.org/10.1371/journal.pone.0209392

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Breast cancer
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Cancer treatment
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Apoptosis
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