Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution

• Oliver Grottke ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft

  * E-mail: ogrottke@ukaachen.de

  Affiliation Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany

  http://orcid.org/0000-0002-0722-3122

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• Joanne van Ryn,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of CardioMetabolic Diseases Research, Boehringer Ingelheim GmbH & Co. KG, Biberach, Germany

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• Christian Zentai,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany

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• Guanfa Gan,

  Roles Investigation, Writing – review & editing

  Affiliation Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, United States of America

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• Markus Honickel,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany

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• Rolf Rossaint,

  Roles Writing – review & editing

  Affiliation Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany

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• Hugo ten Cate,

  Roles Resources, Writing – review & editing

  Affiliation Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

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• Henri M. H. Spronk

  Roles Investigation, Writing – review & editing

  Affiliation Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

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