Evolutionary analysis of the Chikungunya virus epidemic in Mexico reveals intra-host mutational hotspots in the E1 protein

• José Esteban Muñoz-Medina ,

  Contributed equally to this work with: José Esteban Muñoz-Medina, Miguel Antonio Garcia-Knight, Alejandro Sanchez-Flores

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: eban10@hotmail.com (JEMM); miguel.garciaknight@ucsf.edu (MAGK); alexsf@ibt.unam.mx (ASF)

  Affiliation Laboratorio Central de Epidemiología, Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social, Mexico City, Mexico

  http://orcid.org/0000-0002-1289-4457

  ⨯
• Miguel Antonio Garcia-Knight ,

  Contributed equally to this work with: José Esteban Muñoz-Medina, Miguel Antonio Garcia-Knight, Alejandro Sanchez-Flores

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: eban10@hotmail.com (JEMM); miguel.garciaknight@ucsf.edu (MAGK); alexsf@ibt.unam.mx (ASF)

  Current address: Department of Microbiology and Immunology, University of California, San Francisco, California, United States

  Affiliation Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico

  ⨯
• Alejandro Sanchez-Flores ,

  Contributed equally to this work with: José Esteban Muñoz-Medina, Miguel Antonio Garcia-Knight, Alejandro Sanchez-Flores

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: eban10@hotmail.com (JEMM); miguel.garciaknight@ucsf.edu (MAGK); alexsf@ibt.unam.mx (ASF)

  Affiliation Unidad Universitaria de Secuenciación Masiva y Bioinformática, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico

  ⨯
• Irma Eloísa Monroy-Muñoz,

  Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratorio de Genómica, Departamento de Genética y Genómica Humana, Instituto Nacional de Perinatología “Isidro Espinosa de los Reyes”, Mexico City, México

  ⨯
• Ricardo Grande,

  Roles Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Unidad Universitaria de Secuenciación Masiva y Bioinformática, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico

  ⨯
• Joakim Esbjörnsson,

  Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Systems Virology, Department of Laboratory Medicine, Lund University, Lund, Sweden, NDM Research Building, Nuffield Department Medicine, University of Oxford, Oxford, United Kingdom

  ⨯
• Clara Esperanza Santacruz-Tinoco,

  Roles Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratorio Central de Epidemiología, Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social, Mexico City, Mexico

  ⨯
• César Raúl González-Bonilla

  Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Mexico City, Mexico

  ⨯