Influence of pathway topology and functional class on the molecular evolution of human metabolic genes

Ludovica Montanucci; Hafid Laayouni; Begoña Dobon; Kevin L. Keys; Jaume Bertranpetit; Juli Peretó

doi:10.1371/journal.pone.0208782

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Open Access

Peer-reviewed

Research Article

Influence of pathway topology and functional class on the molecular evolution of human metabolic genes

Ludovica Montanucci,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Software, Writing – original draft, Writing – review & editing

Affiliation IBE Evolutionary Biology Institute (CSIC- UPF), Universitat Pompeu Fabra, PRBB, Barcelona, Catalonia, Spain
⨯
Hafid Laayouni,

Roles Data curation, Investigation, Resources, Writing – original draft, Writing – review & editing

Affiliations IBE Evolutionary Biology Institute (CSIC- UPF), Universitat Pompeu Fabra, PRBB, Barcelona, Catalonia, Spain, Bioinformatics Studies, ESCI-UPF, Barcelona, Catalonia, Spain
⨯
Begoña Dobon,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation IBE Evolutionary Biology Institute (CSIC- UPF), Universitat Pompeu Fabra, PRBB, Barcelona, Catalonia, Spain
⨯
Kevin L. Keys,

Roles Data curation, Formal analysis, Investigation

Affiliations IBE Evolutionary Biology Institute (CSIC- UPF), Universitat Pompeu Fabra, PRBB, Barcelona, Catalonia, Spain, UCLA David Geffen School of Medicine, Los Angeles, California, United States of America
⨯
Jaume Bertranpetit ,

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: jaume.bertranpetit@upf.edu

Affiliation IBE Evolutionary Biology Institute (CSIC- UPF), Universitat Pompeu Fabra, PRBB, Barcelona, Catalonia, Spain

http://orcid.org/0000-0003-0100-0590

⨯
Juli Peretó

Roles Conceptualization, Data curation, Methodology, Resources, Writing – original draft, Writing – review & editing

Affiliation Institute of Systems Biology, Department of Biochemistry and Molecular Biology, University of Valencia, Valencia, Spain
⨯

Influence of pathway topology and functional class on the molecular evolution of human metabolic genes

Ludovica Montanucci,
Hafid Laayouni,
Begoña Dobon,
Kevin L. Keys,
Jaume Bertranpetit,
Juli Peretó

Published: December 14, 2018
https://doi.org/10.1371/journal.pone.0208782
See the preprint

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Metabolic pathways
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Enzyme metabolism
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Enzymes
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Centrality
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Metabolic networks
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Molecular evolution
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