A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes

• Makiko Taira ,

  Contributed equally to this work with: Makiko Taira, Minako Imamura, Shiro Maeda

  Roles Formal analysis, Investigation, Writing – original draft

  Affiliation Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan

  ⨯
• Minako Imamura ,

  Contributed equally to this work with: Makiko Taira, Minako Imamura, Shiro Maeda

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan, Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan, Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Okinawa, Japan

  ⨯
• Atsushi Takahashi,

  Roles Data curation, Formal analysis

  Affiliations Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan, Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Osaka, Japan

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• Yoichiro Kamatani,

  Roles Formal analysis

  Affiliations Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan, Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

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• Toshimasa Yamauchi,

  Roles Funding acquisition, Supervision

  Affiliation Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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• Shin-ichi Araki,

  Roles Resources, Validation

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

  ⨯
• Nobue Tanaka,

  Roles Resources, Validation

  Affiliation Diabetes Center, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

  ⨯
• Natalie R. van Zuydam,

  Roles Validation

  Affiliations Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford Center for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Emma Ahlqvist,

  Roles Validation

  Affiliation Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden

  ⨯
• Masao Toyoda,

  Roles Resources, Validation

  Affiliation Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan

  ⨯
• Tomoya Umezono,

  Roles Resources, Validation

  Affiliation Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan

  ⨯
• Koichi Kawai,

  Roles Resources

  Affiliation Kawai Clinic, Ibaragi, Japan

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• Masahito Imanishi,

  Roles Resources

  Affiliations Division of Nephrology and Hypertension, Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan, Department of Nephrology, and Hemodialysis Unit, Ishikiriseiki Hospital, Higashi-Osaka, Japan

  ⨯
• Hirotaka Watada,

  Roles Resources

  Affiliations Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan

  ⨯
• Daisuke Suzuki,

  Roles Resources

  Affiliation Suzuki Diabetes Clinic, Kanagawa, Japan

  ⨯
• Hiroshi Maegawa,

  Roles Resources

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

  ⨯
• Tetsuya Babazono,

  Roles Resources

  Affiliation Diabetes Center, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

  ⨯
• Kohei Kaku,

  Roles Resources

  Affiliation Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan

  ⨯
• Ryuzo Kawamori,

  Roles Resources

  Affiliation Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan

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• The SUMMIT Consortium ,

  ¶The complete membership of the author group can be found in the Acknowledgments

  ⨯
• Leif C. Groop,

  Roles Validation

  Affiliations Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

  ⨯
• Mark I. McCarthy,

  Roles Validation

  Affiliations Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford Center for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford NIHR BIOMEDICAL Research Centre, Oxford University Hospitals Trust, Oxford, United Kingdom

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• Takashi Kadowaki,

  Roles Funding acquisition, Supervision

  Affiliations Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Department of Metabolism and Nutrition, Mizonokuchi Hospital, Faculty of Medicine, Teikyo University, Kanagawa, Japan

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•  [ ... ],
• Shiro Maeda

  Contributed equally to this work with: Makiko Taira, Minako Imamura, Shiro Maeda

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft

  * E-mail: smaeda@med.u-ryukyu.ac.jp

  Affiliations Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan, Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan, Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Okinawa, Japan

  http://orcid.org/0000-0001-6688-9875

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