Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

• Wolfgang Klein ,

  Contributed equally to this work with: Wolfgang Klein, Claudia Rutz

  Roles Data curation, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

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• Claudia Rutz ,

  Contributed equally to this work with: Wolfgang Klein, Claudia Rutz

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

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• Jamina Eckhard,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

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• Becky Provinciael,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation KU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium

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• Edgar Specker,

  Roles Data curation, Investigation, Methodology, Validation, Visualization

  Affiliation Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

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• Martin Neuenschwander,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

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• Gunnar Kleinau,

  Roles Conceptualization, Data curation, Methodology, Software, Supervision, Validation, Visualization

  Affiliation Charité—Universitätsmedizin Berlin, Campus Charité Mitte, Charité Centrum Grundlagenmedizin CC2, Institut für Medizinische Physik und Biophysik, Group Protein X-ray Crystallography & Signal Transduction, Berlin, Germany

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• Patrick Scheerer,

  Roles Conceptualization, Data curation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Charité—Universitätsmedizin Berlin, Campus Charité Mitte, Charité Centrum Grundlagenmedizin CC2, Institut für Medizinische Physik und Biophysik, Group Protein X-ray Crystallography & Signal Transduction, Berlin, Germany

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• Jens-Peter von Kries,

  Roles Conceptualization, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

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• Marc Nazaré,

  Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

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• Kurt Vermeire,

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation KU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium

  http://orcid.org/0000-0003-1123-1907

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• Ralf Schülein

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: schuelein@fmp-berlin.de

  Affiliation Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

  http://orcid.org/0000-0001-5921-9486

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