Adipose-derived autotaxin regulates inflammation and steatosis associated with diet-induced obesity

J. Anthony Brandon; Maria Kraemer; Julia Vandra; Suchismita Halder; Margo Ubele; Andrew J. Morris; Susan S. Smyth

doi:10.1371/journal.pone.0208099

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Open Access

Peer-reviewed

Research Article

Adipose-derived autotaxin regulates inflammation and steatosis associated with diet-induced obesity

J. Anthony Brandon ,

Contributed equally to this work with: J. Anthony Brandon, Maria Kraemer

Roles Conceptualization, Formal analysis, Investigation, Project administration

Affiliation Division of Cardiovascular Medicine, The Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, United States of America
⨯
Maria Kraemer ,

Contributed equally to this work with: J. Anthony Brandon, Maria Kraemer

Roles Conceptualization, Data curation, Formal analysis, Investigation

Affiliation Division of Cardiovascular Medicine, The Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, United States of America
⨯
Julia Vandra,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Division of Cardiovascular Medicine, The Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, United States of America
⨯
Suchismita Halder,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Division of Cardiovascular Medicine, The Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, United States of America
⨯
Margo Ubele,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Division of Cardiovascular Medicine, The Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, United States of America
⨯
Andrew J. Morris,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations Division of Cardiovascular Medicine, The Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, United States of America, Department of Veterans Affairs Medical Center, Lexington, Kentucky, United States of America
⨯
Susan S. Smyth

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: SusanSmyth@uky.edu

Affiliations Division of Cardiovascular Medicine, The Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, United States of America, Department of Veterans Affairs Medical Center, Lexington, Kentucky, United States of America

http://orcid.org/0000-0002-0651-1149

⨯

Adipose-derived autotaxin regulates inflammation and steatosis associated with diet-induced obesity

J. Anthony Brandon,
Maria Kraemer,
Julia Vandra,
Suchismita Halder,
Margo Ubele,
Andrew J. Morris,
Susan S. Smyth

Published: February 7, 2019
https://doi.org/10.1371/journal.pone.0208099

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Adipose tissue
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Fatty liver
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Gene expression
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Inflammation
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Lipids
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Diet
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Obesity
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Adipocytes
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