Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients

Francesco Damin; Silvia Galbiati; Nadia Soriani; Valentina Burgio; Monica Ronzoni; Maurizio Ferrari; Marcella Chiari

doi:10.1371/journal.pone.0207876

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Open Access

Peer-reviewed

Research Article

Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients

Francesco Damin ,

Contributed equally to this work with: Francesco Damin, Silvia Galbiati

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: francesco.damin@icrm.cnr.it

Affiliation Istituto di Chimica del Riconoscimento Molecolare, CNR, Milano, Italy

http://orcid.org/0000-0003-1780-7823

⨯
Silvia Galbiati ,

Contributed equally to this work with: Francesco Damin, Silvia Galbiati

Roles Investigation, Methodology, Validation, Writing – review & editing

Affiliation Unit of Genomic for the Diagnosis of Human Pathologies, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy
⨯
Nadia Soriani,

Roles Validation, Visualization

Affiliation Unit of Genomic for the Diagnosis of Human Pathologies, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy
⨯
Valentina Burgio,

Roles Validation, Visualization

Affiliation Dipartimento di Oncologia Medica, IRCCS Ospedale San Raffaele, Milan, Italy
⨯
Monica Ronzoni,

Roles Validation, Visualization

Affiliation Dipartimento di Oncologia Medica, IRCCS Ospedale San Raffaele, Milan, Italy
⨯
Maurizio Ferrari,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliations Unit of Genomic for the Diagnosis of Human Pathologies, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy, Laboratory of Clinical Molecular Biology, IRCCS Ospedale San Raffaele, Milan, Italy, Università Vita-Salute San Raffaele, Milan, Italy
⨯
Marcella Chiari

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Istituto di Chimica del Riconoscimento Molecolare, CNR, Milano, Italy
⨯

Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients

Francesco Damin,
Silvia Galbiati,
Nadia Soriani,
Valentina Burgio,
Monica Ronzoni,
Maurizio Ferrari,
Marcella Chiari

Published: December 18, 2018
https://doi.org/10.1371/journal.pone.0207876

Reader Comments (3)

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21 Dec 2018
08:49 GMT
Most Recent

Correction to reference 34. Posted by fdamin on 21 Dec 2018 at 08:49 GMT
1 Response

20 Dec 2018
10:38 GMT
Most Recent

34.references in both html and pdf should be corrected. Posted by hkodaz593 on 19 Dec 2018 at 21:45 GMT

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Mutation detection
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Polymerase chain reaction
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Point mutation
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Microarrays
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Oligonucleotides
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Colorectal cancer
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Biopsy
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Mutation
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