Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors

Patrick Sieber; Anny Schäfer; Raphael Lieberherr; François Le Goff; Manuel Stritt; Richard W. D. Welford; John Gatfield; Oliver Peter; Oliver Nayler; Urs Lüthi

doi:10.1371/journal.pone.0207872

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Open Access

Peer-reviewed

Research Article

Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP₂ and EP₄ receptors

Patrick Sieber ,

Roles Conceptualization, Data curation, Formal analysis, Project administration, Supervision, Writing – original draft

* E-mail: patrick.sieber@idorsia.com

¶‡ These authors are joint senior authors on this work.

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland

http://orcid.org/0000-0003-4104-5312

⨯
Anny Schäfer ,

Contributed equally to this work with: Anny Schäfer, Raphael Lieberherr

Roles Formal analysis, Investigation

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Raphael Lieberherr ,

Contributed equally to this work with: Anny Schäfer, Raphael Lieberherr

Roles Formal analysis, Investigation

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland

http://orcid.org/0000-0003-0420-6981

⨯
François Le Goff,

Roles Formal analysis, Investigation

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Manuel Stritt,

Roles Conceptualization, Software, Supervision

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Richard W. D. Welford,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
John Gatfield,

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Oliver Peter,

Roles Resources, Supervision

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Oliver Nayler,

Roles Resources, Supervision, Writing – review & editing

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Urs Lüthi

Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – review & editing

¶‡ These authors are joint senior authors on this work.

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯

Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP₂ and EP₄ receptors

Patrick Sieber,
Anny Schäfer,
Raphael Lieberherr,
François Le Goff,
Manuel Stritt,
Richard W. D. Welford,
John Gatfield,
Oliver Peter,
Oliver Nayler,
Urs Lüthi

Published: November 28, 2018
https://doi.org/10.1371/journal.pone.0207872

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Fibroblasts
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Signal inhibition
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Cell differentiation
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Tubulins
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Pulmonary fibrosis
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Glycosides
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