Solid peripheral tumor leads to systemic inflammation, astrocyte activation and signs of behavioral despair in mice

• Melanie Demers ,

  Contributed equally to this work with: Melanie Demers, Georgette L. Suidan

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Current address: Bioverativ, A Sanofi company, Waltham, Massachusetts, United States of America

  Affiliations Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

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• Georgette L. Suidan ,

  Contributed equally to this work with: Melanie Demers, Georgette L. Suidan

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: Georgette.Suidan@biogen.com (GLS); Denisa.Wagner@childrens.harvard.edu (DDW)

  Current address: Biogen Inc., Cambridge, Massachusetts, United States of America

  Affiliations Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-1617-9813

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• Nick Andrews,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Kirby Neurobiology Center, Boston, Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Kimberly Martinod,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Current address: Department of Cardiovascular Sciences, KU Leuven, Belgium

  Affiliations Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Graduate Program in Immunology, Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-1026-6107

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• Jessica E. Cabral,

  Roles Data curation, Methodology, Writing – review & editing

  Current address: Pfizer Inc., Cambridge, Massachusetts, United States of America

  Affiliation Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America

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• Denisa D. Wagner

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: Georgette.Suidan@biogen.com (GLS); Denisa.Wagner@childrens.harvard.edu (DDW)

  Affiliations Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-4494-413X

  ⨯