Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes

Christopher D. Macdonald; Adrian M. D. Falconer; Chun Ming Chan; David J. Wilkinson; Andrew Skelton; Louise Reynard; Gary J. Litherland; G. Nicholas Europe-Finner; Andrew D. Rowan

doi:10.1371/journal.pone.0207240

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Open Access

Peer-reviewed

Research Article

Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes

Christopher D. Macdonald ,

Contributed equally to this work with: Christopher D. Macdonald, Adrian M. D. Falconer

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Current address: Arthritis Research UK, London, United Kingdom

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Adrian M. D. Falconer ,

Contributed equally to this work with: Christopher D. Macdonald, Adrian M. D. Falconer

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Chun Ming Chan,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
David J. Wilkinson,

Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Andrew Skelton,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Louise Reynard,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Gary J. Litherland,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Validation, Writing – review & editing

Current address: School of Health and Life Sciences, University of the West of Scotland, Paisley Campus, Paisley, Scotland

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
G. Nicholas Europe-Finner,

Roles Data curation, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Andrew D. Rowan

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: drew.rowan@ncl.ac.uk

Affiliation Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom

http://orcid.org/0000-0002-5338-1295

⨯

Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes

Christopher D. Macdonald,
Adrian M. D. Falconer,
Chun Ming Chan,
David J. Wilkinson,
Andrew Skelton,
Louise Reynard,
Gary J. Litherland,
G. Nicholas Europe-Finner,
Andrew D. Rowan

Published: November 15, 2018
https://doi.org/10.1371/journal.pone.0207240

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Chondrocytes
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Small interfering RNA
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Transcriptional control
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Protein synthesis
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