Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest

Linghui Yang; Jing Wang; Yan Deng; Cansheng Gong; Qin Li; Qiu Chen; Huan Li; Chunling Jiang; Ronghua Zhou; Kerong Hai; Wei Wu; Tao Li

doi:10.1371/journal.pone.0207098

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Open Access

Peer-reviewed

Research Article

Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest

Linghui Yang,

Roles Data curation, Formal analysis, Validation

Affiliation Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China
⨯
Jing Wang,

Roles Data curation, Formal analysis

Affiliation Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China
⨯
Yan Deng,

Roles Data curation, Software

Affiliations Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China, West China–Washington Mitochondria and Metabolism Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China, Department of Anesthesiology, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China
⨯
Cansheng Gong,

Roles Data curation

Affiliation Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China
⨯
Qin Li,

Roles Data curation

Affiliations Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China, Department of Anesthesiology, General Hospital of Chengdu Military Area Command, Chengdu, Sichuan, P.R. China
⨯
Qiu Chen,

Roles Data curation

Affiliations Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China, West China–Washington Mitochondria and Metabolism Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China
⨯
Huan Li,

Roles Data curation

Affiliation Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China
⨯
Chunling Jiang,

Roles Data curation

Affiliations Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China, Department of Anesthesiology, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China
⨯
Ronghua Zhou,

Roles Data curation

Affiliations Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China, Department of Anesthesiology, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China
⨯
Kerong Hai,

Roles Data curation

Affiliation Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China
⨯
Wei Wu,

Roles Data curation, Formal analysis

Affiliation Department of Anesthesiology, General Hospital of Chengdu Military Area Command, Chengdu, Sichuan, P.R. China
⨯
Tao Li

Roles Supervision, Writing – review & editing

* E-mail: scutaoli1981@scu.edu.cn

Affiliations Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China, West China–Washington Mitochondria and Metabolism Center, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China, Department of Anesthesiology, West China Hospital of Sichuan University, Sichuan, Chengdu, P.R. China

http://orcid.org/0000-0002-7988-3090

⨯

Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest

Linghui Yang,
Jing Wang,
Yan Deng,
Cansheng Gong,
Qin Li,
Qiu Chen,
Huan Li,
Chunling Jiang,
Ronghua Zhou,
Kerong Hai

Published: November 6, 2018
https://doi.org/10.1371/journal.pone.0207098

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Melatonin
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Mitochondria
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Cardiac arrest
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