A computational strategy for finding novel targets and therapeutic compounds for opioid dependence

• Xiaojun Wu ,

  Contributed equally to this work with: Xiaojun Wu, Siwei Xie

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

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• Siwei Xie ,

  Contributed equally to this work with: Xiaojun Wu, Siwei Xie

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

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• Lirong Wang,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Peihao Fan,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Songwei Ge,

  Roles Software, Writing – review & editing

  Affiliation School of Information, Renmin University of China, Beijing, China

  http://orcid.org/0000-0001-9710-4698

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• Xiang-Qun Xie,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Structural Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Wei Wu

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: weiwu2@cs.cmu.edu

  Affiliation Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

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