hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction

Manti Guha; Satish Srinivasan; F. Bradley Johnson; Gordon Ruthel; Kip Guja; Miguel Garcia-Diaz; Brett A. Kaufman; M. Rebecca Glineburg; JiKang Fang; Hiroshi Nakagawa; Jeelan Basha; Tapas Kundu; Narayan G. Avadhani

doi:10.1371/journal.pone.0206897

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Open Access

Peer-reviewed

Research Article

hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction

Manti Guha,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Resources, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Satish Srinivasan,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
F. Bradley Johnson,

Roles Investigation, Resources, Writing – review & editing

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Gordon Ruthel,

Roles Conceptualization, Methodology, Software, Visualization

Affiliation Penn Vet Imaging Core, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Kip Guja,

Roles Methodology, Software, Visualization

Affiliation Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, United States of America
⨯
Miguel Garcia-Diaz,

Roles Formal analysis, Investigation, Methodology, Software, Visualization

Affiliation Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, United States of America
⨯
Brett A. Kaufman,

Roles Resources

Affiliation Vascular Medicine Institute, University of Pittsburg, Pittsburgh, PA United States of America
⨯
M. Rebecca Glineburg,

Roles Investigation

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
JiKang Fang,

Roles Methodology

Affiliation Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Hiroshi Nakagawa,

Roles Resources

Affiliation Department of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Jeelan Basha,

Roles Resources

Affiliation Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India
⨯
Tapas Kundu,

Roles Resources

Affiliation Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India
⨯
Narayan G. Avadhani

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

* E-mail: narayan@vet.upenn.edu

Affiliation Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

http://orcid.org/0000-0001-6496-6232

⨯

hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction

Manti Guha,
Satish Srinivasan,
F. Bradley Johnson,
Gordon Ruthel,
Kip Guja,
Miguel Garcia-Diaz,
Brett A. Kaufman,
M. Rebecca Glineburg,
JiKang Fang,
Hiroshi Nakagawa

Published: November 14, 2018
https://doi.org/10.1371/journal.pone.0206897

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Telomeres
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Mitochondrial DNA
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Mitochondria
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Telomere length
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Acetylation
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DNA damage
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DNA-binding proteins
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Cellular stress responses
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