Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis

• Ishfaq Ahmed,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft

  Affiliation Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas, United States of America

  ⨯
• Badal C. Roy,

  Roles Investigation, Methodology, Validation

  Affiliation Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas, United States of America

  ⨯
• Rita-Marie T. Raach,

  Roles Investigation, Software

  Affiliation Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America

  ⨯
• Sarah M. Owens,

  Roles Methodology

  Affiliation Biosciences Division, Argonne National Laboratory, Lemont, Illinois, United States of America

  ⨯
• Lijun Xia,

  Roles Resources

  Affiliation Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma, United States of America

  ⨯
• Shrikant Anant,

  Roles Resources, Supervision, Validation

  Affiliation Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas, United States of America

  ⨯
• Venkatesh Sampath,

  Roles Formal analysis, Resources

  Affiliation Division of Neonatology, Children’s Mercy Hospital, Kansas City, Missouri, United States of America

  ⨯
• Shahid Umar

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: sumar@kumc.edu

  Affiliation Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas, United States of America

  http://orcid.org/0000-0003-0579-6813

  ⨯