Nasal immunization with recombinant chimeric pneumococcal protein and cell wall from immunobiotic bacteria improve resistance of infant mice to Streptococcus pneumoniae infection

Jonathan Laiño; Julio Villena; Alexander Suvorov; Hortensia Zelaya; Ramiro Ortiz Moyano; Susana Salva; Susana Alvarez

doi:10.1371/journal.pone.0206661

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Peer-reviewed

Research Article

Nasal immunization with recombinant chimeric pneumococcal protein and cell wall from immunobiotic bacteria improve resistance of infant mice to Streptococcus pneumoniae infection

Jonathan Laiño ,

Contributed equally to this work with: Jonathan Laiño, Julio Villena

Roles Conceptualization, Formal analysis, Investigation

Affiliation Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina

http://orcid.org/0000-0003-0739-8384

⨯
Julio Villena ,

Contributed equally to this work with: Jonathan Laiño, Julio Villena

Roles Conceptualization, Formal analysis, Supervision, Writing – original draft

* E-mail: jcvillena@cerela.org.ar (JV); Alexander_suvorov1@hotmail.com (AS); salvarez@cerela.org.ar (SA)

Affiliation Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina

http://orcid.org/0000-0003-4941-4960

⨯
Alexander Suvorov ,

Roles Conceptualization, Formal analysis, Funding acquisition

* E-mail: jcvillena@cerela.org.ar (JV); Alexander_suvorov1@hotmail.com (AS); salvarez@cerela.org.ar (SA)

Affiliations Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”, Saint-Petersburg, Russia, Saint-Petersburg State University, Saint-Petersburg, Russia
⨯
Hortensia Zelaya,

Roles Formal analysis, Investigation, Methodology

Affiliation Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina
⨯
Ramiro Ortiz Moyano,

Roles Investigation, Methodology

Affiliation Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina
⨯
Susana Salva,

Roles Formal analysis, Investigation, Methodology

Affiliation Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina
⨯
Susana Alvarez

Roles Formal analysis, Funding acquisition, Supervision

* E-mail: jcvillena@cerela.org.ar (JV); Alexander_suvorov1@hotmail.com (AS); salvarez@cerela.org.ar (SA)

Affiliation Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina
⨯

Nasal immunization with recombinant chimeric pneumococcal protein and cell wall from immunobiotic bacteria improve resistance of infant mice to Streptococcus pneumoniae infection

Jonathan Laiño,
Julio Villena,
Alexander Suvorov,
Hortensia Zelaya,
Ramiro Ortiz Moyano,
Susana Salva,
Susana Alvarez

Published: November 5, 2018
https://doi.org/10.1371/journal.pone.0206661

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Cell walls
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Pneumococcus
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