Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke

• John W. Cole ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jcole@som.umaryland.edu

  Affiliation Veterans Affairs Maryland Health Care System; University of Maryland School of Medicine, Baltimore, MD, United States of America

  http://orcid.org/0000-0001-9263-8930

  ⨯
• Huichun Xu,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation University of Maryland School of Medicine, Baltimore, MD, United States of America

  ⨯
• Kathleen Ryan,

  Roles Formal analysis, Writing – review & editing

  Affiliation University of Maryland School of Medicine, Baltimore, MD, United States of America

  ⨯
• Thomas Jaworek,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation University of Maryland School of Medicine, Baltimore, MD, United States of America

  ⨯
• Nicole Dueker,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation University of Miami, Miami, Florida, United States of America

  ⨯
• Patrick McArdle,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation University of Maryland School of Medicine, Baltimore, MD, United States of America

  ⨯
• Brady Gaynor,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation University of Maryland School of Medicine, Baltimore, MD, United States of America

  http://orcid.org/0000-0002-4142-0613

  ⨯
• Yu-Ching Cheng,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Food and Drug Administration, White Oak, MD, United States of America

  ⨯
• Jeffrey O'Connell,

  Roles Methodology, Writing – review & editing

  Affiliation University of Maryland School of Medicine, Baltimore, MD, United States of America

  ⨯
• Steve Bevan,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation University of Lincoln, Lincoln, United Kingdom

  ⨯
• Rainer Malik,

  Roles Methodology, Writing – review & editing

  Affiliation Klinikum der Universität München, Munich, Germany

  ⨯
• Naveed Uddin Ahmed,

  Roles Data curation, Writing – review & editing

  Affiliation Liaquat National Hospital, Karachi, Pakistan

  ⨯
• Philippe Amouyel,

  Roles Data curation, Writing – review & editing

  Affiliation Inserm, Lille, France

  ⨯
• Sheraz Anjum,

  Roles Data curation, Writing – review & editing

  Affiliation Center for Non-Communicable Diseases, Karachi, Pakistan

  ⨯
• Joshua C. Bis,

  Roles Data curation, Writing – review & editing

  Affiliation University of Washington, Seattle, WA, United States of America

  ⨯
• David Crosslin,

  Roles Data curation, Writing – review & editing

  Affiliation University of Washington, Seattle, WA, United States of America

  ⨯
• John Danesh,

  Roles Data curation, Writing – review & editing

  Affiliation University of Cambridge, Cambridge, United Kingdom

  ⨯
• Stefan T. Engelter,

  Roles Data curation, Writing – review & editing

  Affiliation University Hospital Basel, Basel, Switzerland

  ⨯
• Myriam Fornage,

  Roles Data curation, Writing – review & editing

  Affiliation University of Texas Health Science Center at Houston, Houston, TX, United States of America

  ⨯
• Philippe Frossard,

  Roles Data curation, Writing – review & editing

  Affiliation Center for Non-Communicable Diseases, Karachi, Pakistan

  ⨯
• Christian Gieger,

  Roles Data curation, Writing – review & editing

  Affiliation Helmholtz Zentrum München, München, Germany

  ⨯
• Anne-Katrin Giese,

  Roles Data curation, Writing – review & editing

  Affiliation Massachusetts General Hospital, Boston, MA, United States of America

  ⨯
• Caspar Grond-Ginsbach,

  Roles Data curation, Writing – review & editing

  Affiliation Heidelberg University, Heidelberg, Germany

  ⨯
• Weang Kee Ho,

  Roles Data curation, Writing – review & editing

  Affiliation University of Cambridge, Cambridge, United Kingdom

  ⨯
• Elizabeth Holliday,

  Roles Data curation, Writing – review & editing

  Affiliation University of Newcastle, Newcastle, Australia

  ⨯
• Jemma Hopewell,

  Roles Data curation, Writing – review & editing

  Affiliation University of Oxford, Oxford, United Kingdom

  ⨯
• M. Hussain,

  Roles Data curation, Writing – review & editing

  Affiliation Center for Non-Communicable Diseases, Karachi, Pakistan

  ⨯
• W. Iqbal,

  Roles Data curation, Writing – review & editing

  Affiliation Lahore General Hospital, Lahore, Pakistan

  ⨯
• S. Jabeen,

  Roles Data curation, Writing – review & editing

  Affiliation Center for Non-Communicable Diseases, Karachi, Pakistan

  ⨯
• Jim Jannes,

  Roles Data curation, Writing – review & editing

  Affiliation University of Adelaide, Adelaide, Australia

  ⨯
• Ayeesha Kamal,

  Roles Data curation, Writing – review & editing

  Affiliation Aga Khan University Hospital, Karachi, Pakistan

  ⨯
• Yoichiro Kamatani,

  Roles Data curation, Writing – review & editing

  Affiliation RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan

  ⨯
• Sandip Kanse,

  Roles Data curation, Writing – review & editing

  Affiliation Institute of Basic Medical Sciences, Oslo, Norway

  ⨯
• Manja Kloss,

  Roles Data curation, Writing – review & editing

  Affiliation Heidelberg University, Heidelberg, Germany

  ⨯
• Mark Lathrop,

  Roles Data curation, Writing – review & editing

  Affiliation McGill University and Québec Innovation Centre, Montreal, Canada

  ⨯
• Didier Leys,

  Roles Data curation, Writing – review & editing

  Affiliation University of Lille; INSERM, Lille, France

  ⨯
• Arne Lindgren,

  Roles Data curation, Writing – review & editing

  Affiliation Lund University, Lund, Sweden

  ⨯
• W. T. Longstreth Jr,

  Roles Data curation, Writing – review & editing

  Affiliation Harborview Medical Center, Seattle, WA, United States of America

  ⨯
• Khalid Mahmood,

  Roles Data curation, Writing – review & editing

  Affiliation Dow University of Health Sciences, Civil Hospital, Karachi, Pakistan

  ⨯
• Christa Meisinger,

  Roles Data curation, Writing – review & editing

  Affiliation Central Hospital of Augsburg, Augsburg, Germany

  ⨯
• Tiina M. Metso,

  Roles Data curation, Writing – review & editing

  Affiliation Helsinki University Central Hospital, Helsinki, Finland

  ⨯
• Thomas Mosley Jr.,

  Roles Data curation, Writing – review & editing

  Affiliation University of Mississippi Medical Center, Jackson, MS, United States of America

  ⨯
• Martina Müller-Nurasyid,

  Roles Data curation, Writing – review & editing

  Affiliation Institute of Medical Informatics, Ludwig-Maximilians-University, Munich, Germany

  ⨯
• Bo Norrving,

  Roles Data curation, Writing – review & editing

  Affiliation Lund University, Lund, Sweden

  ⨯
• Eugenio Parati,

  Roles Data curation, Writing – review & editing

  Affiliation Fondazione IRCCS Istituto Neurologico, Milan, Italy

  ⨯
• Annette Peters,

  Roles Data curation, Writing – review & editing

  Affiliation GSF-National Research Center for Environment and Health, Munich, Germany

  ⨯
• Alessandro Pezzini,

  Roles Data curation, Writing – review & editing

  Affiliation Universita Degli Studi di Brescia, Brescia, Italy

  http://orcid.org/0000-0001-8629-3315

  ⨯
• I. Quereshi,

  Roles Data curation, Writing – review & editing

  Affiliation King Edward Medical University and Mayo Hospital, Lahore, Pakistan

  ⨯
• Asif Rasheed,

  Roles Data curation, Writing – review & editing

  Affiliation Center for Non-Communicable Diseases, Karachi, Pakistan

  ⨯
• A. Rauf,

  Roles Data curation, Writing – review & editing

  Affiliation Center for Non-Communicable Diseases, Karachi, Pakistan

  ⨯
• T. Salam,

  Roles Data curation, Writing – review & editing

  Affiliation Lahore General Hospital, Lahore, Pakistan

  ⨯
• Jess Shen,

  Roles Data curation, Writing – review & editing

  Affiliation Lunenfeld Tenubaum Research Institute, Toronto, Ontario, Canada

  ⨯
• Agnieszka Słowik,

  Roles Data curation, Writing – review & editing

  Affiliation Jagiellonian University Medical College, Krakow, Poland

  ⨯
• Tara Stanne,

  Roles Data curation, Writing – review & editing

  Affiliation Institute of Biomedicine, Gothenburg, Sweden

  ⨯
• Konstantin Strauch,

  Roles Data curation, Writing – review & editing

  Affiliation Ludwig-Maximilians University Munich, Munich, Germany

  ⨯
• Turgut Tatlisumak,

  Roles Data curation, Writing – review & editing

  Affiliation Helsinki University Central Hospital, Helsinki, Finland

  ⨯
• Vincent N. Thijs,

  Roles Data curation, Writing – review & editing

  Affiliation Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia

  http://orcid.org/0000-0002-6614-8417

  ⨯
• Steffen Tiedt,

  Roles Data curation, Writing – review & editing

  Affiliation Institute for Stroke and Dementia Research, Ludwig-Maximilians Universität München, Munich, Germany

  ⨯
• Matthew Traylor,

  Roles Data curation, Writing – review & editing

  Affiliation University of Cambridge, Cambridge, United Kingdom

  ⨯
• Melanie Waldenberger,

  Roles Data curation, Writing – review & editing

  Affiliation Helmholtz Zentrum München, München, Germany

  ⨯
• Matthew Walters,

  Roles Data curation, Writing – review & editing

  Affiliation University of Glasgow, Glasgow, Scotland

  ⨯
• Wei Zhao,

  Roles Data curation, Writing – review & editing

  Affiliation Translational Medicine and Human Genetics, Philadelphia, PA, United States of America

  ⨯
• Giorgio Boncoraglio,

  Roles Data curation, Writing – review & editing

  Affiliation Fondazione IRCCS Istituto Neurologico, Milan, Italy

  ⨯
• Stéphanie Debette,

  Roles Data curation, Writing – review & editing

  Affiliation Bordeaux University, Bordeaux, France

  ⨯
• Christina Jern,

  Roles Data curation, Writing – review & editing

  Affiliation Institute of Biomedicine, Gothenburg, Sweden

  ⨯
• Christopher Levi,

  Roles Data curation, Writing – review & editing

  Affiliation John Hunter Hospital, New Lambton Heights, NSW, Australia

  ⨯
• Hugh Markus,

  Roles Data curation, Writing – review & editing

  Affiliation University of Cambridge, Cambridge, United Kingdom

  ⨯
• James Meschia,

  Roles Data curation, Writing – review & editing

  Affiliation Mayo Clinic, Jacksonville, FL, United States of America

  ⨯
• Arndt Rolfs,

  Roles Data curation, Writing – review & editing

  Affiliation University of Rostock, Rostock, Mecklenburg-Vorpommern, Germany

  ⨯
• Peter Rothwell,

  Roles Data curation, Writing – review & editing

  Affiliation John Radcliffe Hospital, Oxford, United Kingdom

  ⨯
• Danish Saleheen,

  Roles Data curation, Writing – review & editing

  Affiliation University of Pennsylvania, Philadelphia, PA, United States of America

  ⨯
• Sudha Seshadri,

  Roles Data curation, Writing – review & editing

  Affiliation Boston University School of Medicine, Boston, MA, United States of America

  ⨯
• Pankaj Sharma,

  Roles Data curation, Writing – review & editing

  Affiliation Royal Holloway, University of London, London, United Kingdom

  ⨯
• Cathie Sudlow,

  Roles Data curation, Writing – review & editing

  Affiliation University of Edinburgh, Edinburgh, Scotland

  ⨯
• Bradford Worrall,

  Roles Data curation, Writing – review & editing

  Affiliation University of Virginia, Charlottesville, VA, United States of America

  ⨯
• METASTROKE Consortium of the ISGC ,

  ¶Membership of the METASTROKE Consortium of the ISGC and the WTCCC-2 Consortium is provided in the Acknowledgments.

  ⨯
• WTCCC-2 Consortium ,

  ¶Membership of the METASTROKE Consortium of the ISGC and the WTCCC-2 Consortium is provided in the Acknowledgments.

  ⨯
• O. Colin Stine,

  Roles Data curation, Formal analysis, Methodology, Resources, Writing – review & editing

  Affiliation University of Maryland School of Medicine, Baltimore, MD, United States of America

  ⨯
• Steven J. Kittner,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Veterans Affairs Maryland Health Care System; University of Maryland School of Medicine, Baltimore, MD, United States of America

  ⨯
•  [ ... ],
• Braxton D. Mitchell

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation University of Maryland School of Medicine, Baltimore, MD, United States of America

  ⨯
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