Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma

• Gregory M. Shackleford ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: epstein@usc.edu (AEE); shacklef@usc.edu (GMS)

  Affiliation Department of Radiology, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California, United states of America

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• Min Y. Mahdi,

  Roles Data curation, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Radiology, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California, United states of America

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• Rex A. Moats,

  Roles Funding acquisition, Visualization, Writing – review & editing

  Affiliation Department of Radiology, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California, United states of America

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• Debra Hawes,

  Roles Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology, Children’s Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, California, United states of America

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• Hung C. Tran,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Current address: Division of Pediatric Hematology/Oncology, Kaiser Permanente Central Bay, Oakland California, United states of America

  Affiliation Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Pediatrics, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California, United states of America

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• Jonathan L. Finlay,

  Roles Conceptualization, Writing – review & editing

  Current address: Division of Hematology, Oncology, and BMT, Nationwide Children’s Hospital, The Ohio State University, Columbus, Ohio, United states of America

  Affiliations Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Pediatrics, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California, United states of America, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United states of America

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• Tuan Q. Hoang,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United states of America

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• Ellis F. Meng,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliations Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United states of America, Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, California, United states of America

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• Anat Erdreich-Epstein

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: epstein@usc.edu (AEE); shacklef@usc.edu (GMS)

  Affiliations Department of Pathology, Children’s Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, California, United states of America, Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Pediatrics, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California, United states of America, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United states of America

  http://orcid.org/0000-0003-4269-4373

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