Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

• Hao Sun ,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  * E-mail: david.w.piotrowski@pfizer.com (DWP); hsun@seagen.com (HS); vazadn@gmail.com (ADNV)

  Affiliation Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America

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• David W. Piotrowski ,

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  * E-mail: david.w.piotrowski@pfizer.com (DWP); hsun@seagen.com (HS); vazadn@gmail.com (ADNV)

  Affiliation Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America

  http://orcid.org/0000-0002-4659-6300

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• Suvi T. M. Orr,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America

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• Joseph S. Warmus,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America

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• Angela C. Wolford,

  Roles Investigation, Writing – review & editing

  Affiliation Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America

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• Steven B. Coffey,

  Roles Investigation

  Affiliation Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America

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• Kentaro Futatsugi,

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  Affiliation Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America

  http://orcid.org/0000-0003-3137-9212

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• Yinsheng Zhang,

  Roles Investigation, Methodology

  Affiliation Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America

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• Alfin D. N. Vaz

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  * E-mail: david.w.piotrowski@pfizer.com (DWP); hsun@seagen.com (HS); vazadn@gmail.com (ADNV)

  Affiliation Medicine Design, Pfizer Global Research and Development, Groton, Connecticut, United States of America

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