Affinity, potency, efficacy, and selectivity of neurokinin A analogs at human recombinant NK2 and NK1 receptors

Nadia M. J. Rupniak; Elisabetta Perdona; Cristiana Griffante; Palmina Cavallini; Anna Sava; Daniel J. Ricca; Karl B. Thor; Edward C. Burgard; Mauro Corsi

doi:10.1371/journal.pone.0205894

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Open Access

Peer-reviewed

Research Article

Affinity, potency, efficacy, and selectivity of neurokinin A analogs at human recombinant NK2 and NK1 receptors

Nadia M. J. Rupniak ,

Roles Writing – original draft, Writing – review & editing

* E-mail: nrupniak@dignifytherapeutics.com

Affiliation Dignify Therapeutics, Research Triangle Park, North Carolina, United States of America

http://orcid.org/0000-0003-2314-1108

⨯
Elisabetta Perdona,

Roles Formal analysis, Investigation, Writing – original draft

Affiliation Drug Design and Discovery, Aptuit an Evotec Company, Verona, Italy
⨯
Cristiana Griffante,

Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

Affiliation Drug Design and Discovery, Aptuit an Evotec Company, Verona, Italy
⨯
Palmina Cavallini,

Roles Formal analysis, Investigation

Affiliation Drug Design and Discovery, Aptuit an Evotec Company, Verona, Italy
⨯
Anna Sava,

Roles Formal analysis, Investigation, Writing – original draft

Affiliation Drug Design and Discovery, Aptuit an Evotec Company, Verona, Italy
⨯
Daniel J. Ricca,

Roles Conceptualization, Supervision

Affiliation Dignify Therapeutics, Research Triangle Park, North Carolina, United States of America
⨯
Karl B. Thor,

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

Affiliation Dignify Therapeutics, Research Triangle Park, North Carolina, United States of America
⨯
Edward C. Burgard,

Roles Conceptualization, Funding acquisition, Project administration, Supervision

Affiliation Dignify Therapeutics, Research Triangle Park, North Carolina, United States of America
⨯
Mauro Corsi

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

Affiliation Drug Design and Discovery, Aptuit an Evotec Company, Verona, Italy
⨯

Affinity, potency, efficacy, and selectivity of neurokinin A analogs at human recombinant NK2 and NK1 receptors

Nadia M. J. Rupniak,
Elisabetta Perdona,
Cristiana Griffante,
Palmina Cavallini,
Anna Sava,
Daniel J. Ricca,
Karl B. Thor,
Edward C. Burgard,
Mauro Corsi

Published: October 25, 2018
https://doi.org/10.1371/journal.pone.0205894

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