Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy

• Revital Schick ,

  Contributed equally to this work with: Revital Schick, Lucy N. Mekies

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel, The Rappaport Institute, Haifa, Israel, Rappaport Faculty of Medicine, Technion, Haifa, Israel

  ⨯
• Lucy N. Mekies ,

  Contributed equally to this work with: Revital Schick, Lucy N. Mekies

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel, The Rappaport Institute, Haifa, Israel, Rappaport Faculty of Medicine, Technion, Haifa, Israel

  ⨯
• Yuval Shemer,

  Roles Data curation, Formal analysis

  Affiliations Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel, The Rappaport Institute, Haifa, Israel, Rappaport Faculty of Medicine, Technion, Haifa, Israel

  ⨯
• Binyamin Eisen,

  Roles Data curation, Formal analysis

  Affiliations Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel, The Rappaport Institute, Haifa, Israel, Rappaport Faculty of Medicine, Technion, Haifa, Israel

  http://orcid.org/0000-0002-2185-5054

  ⨯
• Tova Hallas,

  Roles Data curation

  Affiliations Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel, The Rappaport Institute, Haifa, Israel, Rappaport Faculty of Medicine, Technion, Haifa, Israel

  ⨯
• Ronen Ben Jehuda,

  Roles Formal analysis

  Affiliations Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel, The Rappaport Institute, Haifa, Israel, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Department of Biotechnology, Technion, Haifa, Israel

  ⨯
• Meital Ben-Ari,

  Roles Data curation

  Affiliations Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel, The Rappaport Institute, Haifa, Israel, Rappaport Faculty of Medicine, Technion, Haifa, Israel

  ⨯
• Agnes Szantai,

  Roles Data curation

  Affiliations Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel, The Rappaport Institute, Haifa, Israel, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Department of Biochemistry, University of Szeged, Szeged, Hungary

  http://orcid.org/0000-0002-8017-5075

  ⨯
• Lubna Willi,

  Roles Data curation

  Affiliations Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel, The Rappaport Institute, Haifa, Israel, Rappaport Faculty of Medicine, Technion, Haifa, Israel

  ⨯
• Rita Shulman,

  Roles Methodology

  Affiliations Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel, The Rappaport Institute, Haifa, Israel, Rappaport Faculty of Medicine, Technion, Haifa, Israel

  ⨯
• Michael Gramlich,

  Roles Resources

  Affiliation Department of Cardiology and Cardiovascular Diseases, Eberhard Karls University, Tübingen, Germany

  ⨯
• Luna Simona Pane,

  Roles Formal analysis

  Affiliation Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

  ⨯
• Ilaria My,

  Roles Data curation

  Affiliation Medical Department–Cardiology, Klinikum rechts der Isar–Technische Universität München, Munich, Germany

  ⨯
• Dov Freimark,

  Roles Resources

  Affiliation Heart Failure Institute and Leviev Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

  ⨯
• Marta Murgia,

  Roles Data curation, Formal analysis

  Affiliations Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Martinsried, Germany, Department of Biomedical Sciences, University of Padova, Padua, Italy

  ⨯
• Gianluca Santamaria,

  Roles Formal analysis

  Affiliation Department of Experimental and Clinical Medicine, University of Magna Grecia, Medical School, Catanzaro, Italy

  ⨯
• Mihaela Gherghiceanu,

  Roles Resources

  Affiliation Victor Babes National Institute of Pathology, Bucharest, Romania

  ⨯
• Michael Arad,

  Roles Conceptualization

  Affiliation Heart Failure Institute and Leviev Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

  ⨯
• Alessandra Moretti,

  Roles Conceptualization, Funding acquisition, Resources

  Affiliations Medical Department–Cardiology, Klinikum rechts der Isar–Technische Universität München, Munich, Germany, German Centre for Cardiovascular Research–partner site Munich Heart Alliance, Munich, Germany

  ⨯
•  [ ... ],
• Ofer Binah

  Roles Conceptualization, Funding acquisition, Resources, Supervision

  * E-mail: binah@tx.technion.ac.il

  Affiliations Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel, The Rappaport Institute, Haifa, Israel, Rappaport Faculty of Medicine, Technion, Haifa, Israel

  http://orcid.org/0000-0002-0468-8530

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