The effects of kinase modulation on in vitro maturation according to different cumulus-oocyte complex morphologies

Bong-Seok Song; Pil-Soo Jeong; Jong-Hee Lee; Moon-Hyung Lee; Hae-Jun Yang; Seon-A Choi; Hwal-Yong Lee; Seung-Bin Yoon; Young-Ho Park; Kang-Jin Jeong; Young-Hyun Kim; Yeung Bae Jin; Ji-Su Kim; Bo-Woong Sim; Jae-Won Huh; Sang-Rae Lee; Deog-Bon Koo; Kyu-Tae Chang; Sun-Uk Kim

doi:10.1371/journal.pone.0205495

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Open Access

Peer-reviewed

Research Article

The effects of kinase modulation on in vitro maturation according to different cumulus-oocyte complex morphologies

Bong-Seok Song ,

Contributed equally to this work with: Bong-Seok Song, Pil-Soo Jeong, Jong-Hee Lee

Roles Conceptualization, Investigation, Writing – original draft

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, Department of Bioscience, University of Science and Technology, Daejeon, Republic of Korea
⨯
Pil-Soo Jeong ,

Contributed equally to this work with: Bong-Seok Song, Pil-Soo Jeong, Jong-Hee Lee

Roles Conceptualization, Investigation, Writing – original draft

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, Department of Biotechnology, College of Engineering, Daegu University, Gyeongbuk, Republic of Korea
⨯
Jong-Hee Lee ,

Contributed equally to this work with: Bong-Seok Song, Pil-Soo Jeong, Jong-Hee Lee

Roles Conceptualization, Validation, Writing – review & editing

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea
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Moon-Hyung Lee,

Roles Investigation, Resources

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, Department of Biotechnology, College of Engineering, Daegu University, Gyeongbuk, Republic of Korea
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Hae-Jun Yang,

Roles Resources

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, Department of Biological Science, College of Natural Sciences, Wonkwang University, Jeollabuk-do, Republic of Korea
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Seon-A Choi,

Roles Investigation

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea
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Hwal-Yong Lee,

Roles Resources

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea
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Seung-Bin Yoon,

Roles Investigation, Validation

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, Primate Resource Center, Korea Research Institute of Bioscience & Biotechnology, Jeollabuk-do, Republic of Korea
⨯
Young-Ho Park,

Roles Funding acquisition, Investigation

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea
⨯
Kang-Jin Jeong,

Roles Resources

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea
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Young-Hyun Kim,

Roles Funding acquisition, Investigation

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
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Yeung Bae Jin,

Roles Formal analysis

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea
⨯
Ji-Su Kim,

Roles Data curation

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, Primate Resource Center, Korea Research Institute of Bioscience & Biotechnology, Jeollabuk-do, Republic of Korea
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Bo-Woong Sim,

Roles Formal analysis

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea
⨯
Jae-Won Huh,

Roles Data curation

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
⨯
Sang-Rae Lee,

Roles Validation

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
⨯
Deog-Bon Koo,

Roles Writing – review & editing

Affiliation Department of Biotechnology, College of Engineering, Daegu University, Gyeongbuk, Republic of Korea
⨯
Kyu-Tae Chang ,

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: sunuk@kribb.re.kr (SUK); changkt@kribb.re.kr (KTC)

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
⨯
[ ... ],
Sun-Uk Kim

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: sunuk@kribb.re.kr (SUK); changkt@kribb.re.kr (KTC)

Affiliations Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk-do, Republic of Korea, Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea

http://orcid.org/0000-0002-5168-6976

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The effects of kinase modulation on in vitro maturation according to different cumulus-oocyte complex morphologies

Bong-Seok Song,
Pil-Soo Jeong,
Jong-Hee Lee,
Moon-Hyung Lee,
Hae-Jun Yang,
Seon-A Choi,
Hwal-Yong Lee,
Seung-Bin Yoon,
Young-Ho Park,
Kang-Jin Jeong

Published: October 11, 2018
https://doi.org/10.1371/journal.pone.0205495

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Oocytes
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MAPK signaling cascades
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Signal inhibition
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Meiosis
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