Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies

• Nicole A. Kratochwil ,

  Contributed equally to this work with: Nicole A. Kratochwil, Stephen R. Dueker, Michael B. Otteneder

  Roles Conceptualization, Data curation, Formal analysis, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft

  * E-mail: nicole_a.kratochwil@roche.com

  ¶‡ NAK, MBO, and SRD are Joint Senior Authors on this work.

  Affiliation Pharmaceutical Sciences and Therapeutic Modalities, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

  http://orcid.org/0000-0002-2149-4375

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• Stephen R. Dueker ,

  Contributed equally to this work with: Nicole A. Kratochwil, Stephen R. Dueker, Michael B. Otteneder

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft

  ¶‡ NAK, MBO, and SRD are Joint Senior Authors on this work.

  Affiliation BioCore Ltd, Seoul, South Korea

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• Dieter Muri,

  Roles Conceptualization, Data curation, Formal analysis, Validation, Writing – original draft

  Affiliation Pharmaceutical Sciences and Therapeutic Modalities, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• Claudia Senn,

  Roles Conceptualization, Data curation, Formal analysis, Validation, Writing – original draft

  Affiliation Pharmaceutical Sciences and Therapeutic Modalities, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• HyeJin Yoon,

  Roles Data curation, Formal analysis

  Affiliation BioCore Ltd, Seoul, South Korea

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• Byung-Yong Yu,

  Roles Data curation, Formal analysis

  Affiliation Korea Institute of Science &Technology, Seoul, South Korea

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• Gwan-Ho Lee,

  Roles Data curation, Formal analysis

  Affiliation Korea Institute of Science &Technology, Seoul, South Korea

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• Feng Dong,

  Roles Conceptualization, Data curation, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Picarro, Inc., Santa Clara, California, United States of America

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• Michael B. Otteneder

  Contributed equally to this work with: Nicole A. Kratochwil, Stephen R. Dueker, Michael B. Otteneder

  Roles Conceptualization, Data curation, Formal analysis, Project administration, Validation, Writing – original draft

  ¶‡ NAK, MBO, and SRD are Joint Senior Authors on this work.

  Affiliation Pharmaceutical Sciences and Therapeutic Modalities, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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