Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening

• Ya Chen ,

  Contributed equally to this work with: Ya Chen, Xia Yuan

  Roles Conceptualization, Investigation, Methodology, Writing – original draft

  Affiliation State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, P. R. China

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• Xia Yuan ,

  Contributed equally to this work with: Ya Chen, Xia Yuan

  Roles Data curation, Methodology

  Affiliation State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, P. R. China

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• Zhangping Xiao,

  Roles Data curation, Methodology, Visualization

  Affiliation State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, P. R. China

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• Hongwei Jin,

  Roles Investigation, Software

  Affiliation State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, P. R. China

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• Liangren Zhang ,

  Roles Funding acquisition, Supervision, Writing – review & editing

  * E-mail: zmliu@bjmu.edu.cn (ZL); liangren@bjmu.edu.cn (LZ)

  Affiliation State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, P. R. China

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• Zhenming Liu

  Roles Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

  * E-mail: zmliu@bjmu.edu.cn (ZL); liangren@bjmu.edu.cn (LZ)

  Affiliation State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, P. R. China

  http://orcid.org/0000-0002-8993-4015

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