Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis

• Shiloh R. Lueschow ,

  Contributed equally to this work with: Shiloh R. Lueschow, Steven J. McElroy

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America

  ⨯
• Jessica Stumphy ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  ¶‡ JS, HG, SLK, TGE, and KMK also contributed equally to this work. MAU, DAM, MHW, DKM, and MG also contributed equally to this work.

  Affiliation Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America

  ⨯
• Huiyu Gong ,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ JS, HG, SLK, TGE, and KMK also contributed equally to this work. MAU, DAM, MHW, DKM, and MG also contributed equally to this work.

  Affiliation Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America

  ⨯
• Stacy L. Kern ,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ JS, HG, SLK, TGE, and KMK also contributed equally to this work. MAU, DAM, MHW, DKM, and MG also contributed equally to this work.

  Affiliation Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America

  ⨯
• Timothy G. Elgin ,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ JS, HG, SLK, TGE, and KMK also contributed equally to this work. MAU, DAM, MHW, DKM, and MG also contributed equally to this work.

  Affiliation Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America

  ⨯
• Mark A. Underwood ,

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ JS, HG, SLK, TGE, and KMK also contributed equally to this work. MAU, DAM, MHW, DKM, and MG also contributed equally to this work.

  Affiliation Departments of Pediatrics and Food Science and Technology, University of California Davis, Sacramento, California, United States of America

  ⨯
• Karen M. Kalanetra ,

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ JS, HG, SLK, TGE, and KMK also contributed equally to this work. MAU, DAM, MHW, DKM, and MG also contributed equally to this work.

  Affiliation Departments of Pediatrics and Food Science and Technology, University of California Davis, Sacramento, California, United States of America

  ⨯
• David A. Mills ,

  Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

  ¶‡ JS, HG, SLK, TGE, and KMK also contributed equally to this work. MAU, DAM, MHW, DKM, and MG also contributed equally to this work.

  Affiliation Departments of Pediatrics and Food Science and Technology, University of California Davis, Sacramento, California, United States of America

  ⨯
• Melissa H. Wong ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  ¶‡ JS, HG, SLK, TGE, and KMK also contributed equally to this work. MAU, DAM, MHW, DKM, and MG also contributed equally to this work.

  Affiliation Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, Oregon, United States of America

  ⨯
• David K. Meyerholz ,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ JS, HG, SLK, TGE, and KMK also contributed equally to this work. MAU, DAM, MHW, DKM, and MG also contributed equally to this work.

  Affiliation Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America

  ⨯
• Misty Good ,

  Roles Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  ¶‡ JS, HG, SLK, TGE, and KMK also contributed equally to this work. MAU, DAM, MHW, DKM, and MG also contributed equally to this work.

  Affiliation Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States of America

  ⨯
• Steven J. McElroy

  Contributed equally to this work with: Shiloh R. Lueschow, Steven J. McElroy

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: steven-mcelroy@uiowa.edu

  Affiliations Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America, Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America

  http://orcid.org/0000-0002-4321-723X

  ⨯