Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

Vladimir Ilievski; Paulina K. Zuchowska; Stefan J. Green; Peter T. Toth; Michael E. Ragozzino; Khuong Le; Haider W. Aljewari; Neil M. O’Brien-Simpson; Eric C. Reynolds; Keiko Watanabe

doi:10.1371/journal.pone.0204941

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Open Access

Peer-reviewed

Research Article

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

Vladimir Ilievski,

Roles Formal analysis, Investigation

Affiliation Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Paulina K. Zuchowska,

Roles Investigation

Affiliation Undergraduate Program, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Stefan J. Green,

Roles Formal analysis

Current address: DNA Core Facility, University of Illinois at Chicago, Chicago, Illinois, United States of America

Affiliation Department of Biological Sciences University of Illinois at Chicago, Chicago, Illinois, Unites States of America
⨯
Peter T. Toth,

Roles Formal analysis

Current address: Fluorescence Imaging Core Facility, University of Illinois at Chicago, Chicago, Illinois, United States of America

Affiliation Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Michael E. Ragozzino,

Roles Methodology

Affiliation Department of Psychology, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Khuong Le,

Roles Investigation

Affiliation Undergraduate Program, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Haider W. Aljewari,

Roles Investigation

Affiliation Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, United States of America

http://orcid.org/0000-0002-1509-3612

⨯
Neil M. O’Brien-Simpson,

Roles Methodology

Affiliation Melbourne Dental School, University of Melbourne, Melbourne, Victoria, Australia
⨯
Eric C. Reynolds,

Roles Methodology

Affiliation Melbourne Dental School, University of Melbourne, Melbourne, Victoria, Australia
⨯
Keiko Watanabe

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

* E-mail: keiko@uic.edu

Affiliation Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, United States of America

http://orcid.org/0000-0001-8764-9539

⨯

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

Vladimir Ilievski,
Paulina K. Zuchowska,
Stefan J. Green,
Peter T. Toth,
Michael E. Ragozzino,
Khuong Le,
Haider W. Aljewari,
Neil M. O’Brien-Simpson,
Eric C. Reynolds,
Keiko Watanabe

Published: October 3, 2018
https://doi.org/10.1371/journal.pone.0204941

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